Evaluation of thermal antinociceptive effects after intramuscular administration of buprenorphine hydrochloride to American kestrels (Falco sparverius)

Susanne M. Ceulemans, David Guzman, Glenn H. Olsen, Hugues Beaufrère, Joanne R Paul-Murphy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective-To evaluate the thermal antinociceptive effects and duration of action of buprenorphine hydrochloride after IM administration to American kestrels (Falco sparverius). Animals-12 healthy 3-year-old American kestrels. Procedures-Buprenorphine hydrochloride (0.1, 0.3, and 0.6 mg/kg) and a control treatment (saline [0.9% NaCl] solution) were administered IM in a randomized crossover experimental design. Foot withdrawal response to a thermal stimulus was determined 1 hour before (baseline) and 1.5, 3, and 6 hours after treatment administration. Agitation-sedation scores were determined 3 to 5 minutes before each thermal stimulus. Adverse effects were monitored for 6 hours after treatment administration. Results-Buprenorphine hydrochloride at 0.1, 0.3, and 0.6 mg/kg, IM, increased thermal threshold for 6 hours, compared with the response for the control treatment. There were no significant differences among buprenorphine treatments. A mild sedative effect was detected at a dose of 0.6 mg of buprenorphine/kg. Conclusion and Clinical Relevance-At the doses tested, buprenorphine hydrochloride resulted in thermal antinociception in American kestrels for at least 6 hours, which suggested that buprenorphine has analgesic effects in this species. Further studies with longer evaluation periods and additional forms of noxious stimuli, formulations, dosages, and routes of administration are needed to fully evaluate the analgesic effects of buprenorphine in American kestrels.

Original languageEnglish (US)
Pages (from-to)705-710
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume75
Issue number8
DOIs
StatePublished - 2014

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Falco sparverius
buprenorphine
Buprenorphine
analgesic effect
intramuscular injection
Hot Temperature
heat
Analgesics
dosage
sedatives
agitation
sedation
Hypnotics and Sedatives
Cross-Over Studies
Foot
Research Design
experimental design
adverse effects
duration

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of thermal antinociceptive effects after intramuscular administration of buprenorphine hydrochloride to American kestrels (Falco sparverius). / Ceulemans, Susanne M.; Guzman, David; Olsen, Glenn H.; Beaufrère, Hugues; Paul-Murphy, Joanne R.

In: American Journal of Veterinary Research, Vol. 75, No. 8, 2014, p. 705-710.

Research output: Contribution to journalArticle

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