Evaluation of thermal antinociceptive effects after intramuscular administration of hydromorphone hydrochloride to American kestrels (Falco sparverius)

David Guzman, Tracy L. Drazenovich, Glenn H. Olsen, Neil H. Willits, Joanne R Paul-Murphy

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Abstract

Objective-To evaluate the antinociceptive and sedative effects and duration of action of hydromorphone hydrochloride after IM administration to American kestrels (Falco sparverius). Animals-11 healthy 2-year-old American kestrels. Procedures-Hydromorphone (0.1, 0.3, and 0.6 mg/kg) and an equivalent volume of saline (0.9% NaCl) solution (control treatment) were administered IM to kestrels in a masked randomized complete crossover study design. Foot withdrawal response to a thermal stimulus was determined 30 to 60 minutes before (baseline) and 0.5, 1.5, 3, and 6 hours after treatment administration. Agitation-sedation scores were determined 3 to 5 minutes before each thermal test. Results-Hydromorphone at 0.6 mg/kg, IM, significantly increased the thermal foot withdrawal threshold, compared with the response after administration of saline solution, for up to 3 hours, and hydromorphone at 0.1, 0.3, and 0.6 mg/kg, IM, significantly increased withdrawal responses for up to 6 hours, compared with baseline values. No significant differences in mean sedation-agitation scores were detected between hydromorphone and saline solution treatments; however, appreciable sedation was detected in 4 birds when administered 0.6 mg of hydromorphone/kg. Conclusions and Clinical Relevance-Hydromorphone at the doses evaluated significantly increased the thermal nociception threshold for American kestrels for 3 to 6 hours. Additional studies with other types of stimulation, formulations, dosages, routes of administration, and testing times are needed to fully evaluate the analgesic and adverse effects of hydromorphone in kestrels and other avian species and the use of hydromorphone in clinical settings.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume74
Issue number6
DOIs
StatePublished - Jun 2013

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Hydromorphone
Falco sparverius
analgesic effect
intramuscular injection
sedation
Hot Temperature
sodium chloride
heat
agitation
nociception
sedatives
dosage
normal values
Sodium Chloride
Cross-Over Studies
Foot
experimental design
adverse effects
testing
duration

ASJC Scopus subject areas

  • veterinary(all)

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Evaluation of thermal antinociceptive effects after intramuscular administration of hydromorphone hydrochloride to American kestrels (Falco sparverius). / Guzman, David; Drazenovich, Tracy L.; Olsen, Glenn H.; Willits, Neil H.; Paul-Murphy, Joanne R.

In: American Journal of Veterinary Research, Vol. 74, No. 6, 06.2013, p. 817-822.

Research output: Contribution to journalArticle

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