Evaluation of the susceptibility of Coccidioides immitis to lufenuron, a chitin synthase inhibitor

S. M. Johnson, C. R. Zimmermann, K. M. Kerekes, A. Davidson, Demosthenes Pappagianis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The activity of the chitin synthase inhibitor lufenuron was evaluated in vitro using the spherule-endospore (SE) phase of Coccidioides immitis. The lufenuron was also used to treat mice infected with C. immitis by the respiratory route. In vitro, lufenuron had no effect upon fungal cell growth. Two formulations of lufenuron were evaluated in vivo. Neither the oral nor the injectable lufenuron extended the survival of mice infected with C. immitis when compared with placebo-treated mice.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalMedical Mycology
Volume37
Issue number6
DOIs
StatePublished - Dec 1999

Keywords

  • Chitin synthase
  • Coccidioides immitis
  • Inhibitor
  • Lufenuron

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

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