The data obtained in forty-two patients with Hodgkin's disease who underwent exploratory laparotomy with splenectomy were analyzed to assess the usefulness of the criteria leading to the interpretation of the preoperative splenic scintigraph. Focal defects and marked splenomegaly indicated Hodgkin's disease in the spleen, although these findings were frequently not present. Other criteria were more sensitive, but less specific indicators of Hodgkin's disease in the spleen. Clinical palpability was a poor method for determining splenic size or involvement with Hodgkin's disease. Pathologic examination remains the most reliable means of detecting Hodgkin's disease in the spleen.
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