Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome

R. K. Desai, I. Jialal, C. Naidoo, M. A. Omar, S. M. Joubert

Research output: Contribution to journalArticle

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Abstract

Twenty-four hour urinary free cortisol and mean and integrated 13h00-16h00 plasma cortisol levels were measured in 9 patients with proven Cushing's syndrome (5 with Cushing's disease, 2 with ectopic adrenocorticotrophic hormone production due to bronchial carcinoma and 2 with adrenal adenomas) and in 21 patients without Cushing's syndrome. The 24-hour urinary free cortisol levels and mean and integrated 13h00-16h00 plasma cortisol estimations clearly distinguished patients with Cushing's syndrome from those without. However, adequate suppression on dexamethasone suppression tests (false negatives) were obtained in 3 of the 9 patients with Cushing's syndrome. Since the integrated 13h00-16h00 plasma cortisol estimation is cheaper and simpler than the mean 13h00-16h00 plasma cortisol estimation, we recommend it as an adjunct in the diagnosis of Cushing's syndrome.

Original languageEnglish (US)
Pages (from-to)156-157
Number of pages2
JournalSouth African Medical Journal
Volume71
Issue number3
StatePublished - 1987
Externally publishedYes

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Cushing Syndrome
Hydrocortisone
Ectopic Hormones
Pituitary ACTH Hypersecretion
Bronchogenic Carcinoma
Adenoma
Adrenocorticotropic Hormone
Dexamethasone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Desai, R. K., Jialal, I., Naidoo, C., Omar, M. A., & Joubert, S. M. (1987). Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome. South African Medical Journal, 71(3), 156-157.

Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome. / Desai, R. K.; Jialal, I.; Naidoo, C.; Omar, M. A.; Joubert, S. M.

In: South African Medical Journal, Vol. 71, No. 3, 1987, p. 156-157.

Research output: Contribution to journalArticle

Desai, RK, Jialal, I, Naidoo, C, Omar, MA & Joubert, SM 1987, 'Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome', South African Medical Journal, vol. 71, no. 3, pp. 156-157.
Desai, R. K. ; Jialal, I. ; Naidoo, C. ; Omar, M. A. ; Joubert, S. M. / Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome. In: South African Medical Journal. 1987 ; Vol. 71, No. 3. pp. 156-157.
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