Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome

R. K. Desai, I. Jialal, C. Naidoo, M. A. Omar, S. M. Joubert

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Twenty-four hour urinary free cortisol and mean and integrated 13h00-16h00 plasma cortisol levels were measured in 9 patients with proven Cushing's syndrome (5 with Cushing's disease, 2 with ectopic adrenocorticotrophic hormone production due to bronchial carcinoma and 2 with adrenal adenomas) and in 21 patients without Cushing's syndrome. The 24-hour urinary free cortisol levels and mean and integrated 13h00-16h00 plasma cortisol estimations clearly distinguished patients with Cushing's syndrome from those without. However, adequate suppression on dexamethasone suppression tests (false negatives) were obtained in 3 of the 9 patients with Cushing's syndrome. Since the integrated 13h00-16h00 plasma cortisol estimation is cheaper and simpler than the mean 13h00-16h00 plasma cortisol estimation, we recommend it as an adjunct in the diagnosis of Cushing's syndrome.

Original languageEnglish (US)
Pages (from-to)156-157
Number of pages2
JournalSouth African Medical Journal
Volume71
Issue number3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Desai, R. K., Jialal, I., Naidoo, C., Omar, M. A., & Joubert, S. M. (1987). Evaluation of the integrated 3-hour plasma cortisol concentration as a test for Cushing's syndrome. South African Medical Journal, 71(3), 156-157.