Evaluation of the effects of ischemic injury and ureteral obstruction on delayed graft function in cats after renal autotransplantation

Margo L. Mehl, Andrew E. Kyles, S. Brent Reimer, Alison K. Flynn, Rachel E. Pollard, Tom Nyland, Philip H. Kass, Stephen M. Griffey, Clare R. Gregory

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective - To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Study Design - Experimental study. Animals - Six intact female cats. Methods - Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured regularly and abdominal ultrasound was performed before surgery, the day after surgery and twice weekly thereafter. Ultrasound-guided renal biopsy was performed on day 7. Cats were euthanatized on day 21. Histology of the autograft, ureter, bladder, vascular anastomoses sites, and contralateral kidney were performed. Observations were compared with those from an historic group of research cats that had extravesicular ureteroneocystostomy and contralateral nephrectomy.1 Results - Five cats completed the study. Serum creatinine and BUN concentrations increased after surgery, peaking at 3.2±0.8 and 77.6±15.9 mg/dL, respectively, 1-2 days after surgery. Serum creatinine concentration returned to the reference interval by 6 days after surgery. BUN gradually decreased in all cats but did not return to the reference interval by study end. Serum creatinine and BUN concentrations were consistently lower but not significantly so (P=.29 and.56, respectively) compared with the historic ureteroneocystostomy group. No ultrasonographic abnormalities or renal biopsy histologic abnormalities were observed. At necropsy, 1 autograft had generalized interstitial fibrosis. Conclusion - Harvesting the renal graft and the ischemia before revascularization causes impaired renal function after engraftment. Clinical Relevance - The process of harvesting and reimplanting the renal graft can contribute to DGF in cats, independent of ureteral obstruction.

Original languageEnglish (US)
Pages (from-to)341-346
Number of pages6
JournalVeterinary Surgery
Volume35
Issue number4
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Evaluation of the effects of ischemic injury and ureteral obstruction on delayed graft function in cats after renal autotransplantation'. Together they form a unique fingerprint.

  • Cite this