Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency

Carol R. Norris, Laurel J Gershwin

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5 Scopus citations

Abstract

Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalJournal of the American Animal Hospital Association
Volume39
Issue number3
StatePublished - May 2003

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ASJC Scopus subject areas

  • veterinary(all)

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