Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency

Carol R. Norris, Laurel J Gershwin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalJournal of the American Animal Hospital Association
Volume39
Issue number3
StatePublished - May 2003

Fingerprint

Irish Setter
immunoglobulin M
immunoglobulin A
immunoglobulin G
Immunoglobulin A
B-lymphocytes
Mucous Membrane
B-Lymphocytes
Coloring Agents
antibodies
dogs
Secretory Immunoglobulin A
Serum
mucosa
secretion
Immunoglobulin M
Immunoglobulin G
Dogs
Antibodies
Bronchoalveolar Lavage Fluid

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{06b2dc5a3c324972a2cf8e15d9f7dd09,
title = "Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency",
abstract = "Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.",
author = "Norris, {Carol R.} and Gershwin, {Laurel J}",
year = "2003",
month = "5",
language = "English (US)",
volume = "39",
pages = "247--250",
journal = "Journal of the American Animal Hospital Association",
issn = "0587-2871",
publisher = "American Animal Hospital Association",
number = "3",

}

TY - JOUR

T1 - Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency

AU - Norris, Carol R.

AU - Gershwin, Laurel J

PY - 2003/5

Y1 - 2003/5

N2 - Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.

AB - Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.

UR - http://www.scopus.com/inward/record.url?scp=0037613823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037613823&partnerID=8YFLogxK

M3 - Article

C2 - 12755197

AN - SCOPUS:0037613823

VL - 39

SP - 247

EP - 250

JO - Journal of the American Animal Hospital Association

JF - Journal of the American Animal Hospital Association

SN - 0587-2871

IS - 3

ER -