Abstract
Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 247-250 |
| Number of pages | 4 |
| Journal | Journal of the American Animal Hospital Association |
| Volume | 39 |
| Issue number | 3 |
| State | Published - May 2003 |
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- veterinary(all)
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Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency. / Norris, Carol R.; Gershwin, Laurel J.
In: Journal of the American Animal Hospital Association, Vol. 39, No. 3, 05.2003, p. 247-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of systemic and secretory lgA concentrations and immunohistochemical stains for lgA-containing B cells in mucosal tissues of an Irish setter with selective lgA deficiency
AU - Norris, Carol R.
AU - Gershwin, Laurel J
PY - 2003/5
Y1 - 2003/5
N2 - Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
AB - Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
UR - http://www.scopus.com/inward/record.url?scp=0037613823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037613823&partnerID=8YFLogxK
M3 - Article
C2 - 12755197
AN - SCOPUS:0037613823
VL - 39
SP - 247
EP - 250
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
SN - 0587-2871
IS - 3
ER -