Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysis.

Hui Sun, Paul A. Yushkevich, Hui Zhang, Philip A. Cook, Jeffrey T. Duda, Tony J Simon, James C. Gee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recently, concerns have been raised that the correspondences computed by volumetric registration within homogeneous structures are primarily driven by regularization priors that differ among algorithms. This paper explores the correspondence based on geometric models for one of those structures, midsagittal section of the corpus callosum (MSCC), and compared the result with registration paradigms. We use geometric model called continuous medial representation (cm-rep) to normalize anatomical structures on the basis of medial geometry, and use features derived from diffusion tensor tractography for validation. We show that shape-based normalization aligns subregions of the MSCC, defined by connectivity, more accurately than normalization based on volumetric registration. Furthermore, shape-based normalization helps increase the statistical power of group analysis in an experiment where features derived from diffusion tensor tractography are compared between two cohorts. These results suggest that cm-rep is an appropriate tool for normalizing the MSCC in white matter studies.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages777-784
Number of pages8
Volume10
EditionPt 2
StatePublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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    Sun, H., Yushkevich, P. A., Zhang, H., Cook, P. A., Duda, J. T., Simon, T. J., & Gee, J. C. (2007). Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysis. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 10, pp. 777-784)