Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic

K. M. Latson, Jorge Nieto, P. M. Beldomenico, J. R. Snyder

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Reasons for performing study: The most common cause of death as a direct result of colic is acute circulatory failure secondary to intestinal ischaemia. Early and accurate recognition of ischaemic bowel is essential to decrease complications and increase survival. Blood to peritoneal lactate values have been evaluated as a prognostic indicator, but lactate values characterised by type of lesion have not been reported. Hypothesis: Plasma and peritoneal lactate values are higher in horses with intestinal ischaemia secondary to a strangulating obstruction (ISSO). Methods: Venous blood and peritoneal fluid were collected sequentially from 20 clinically healthy horses and 189 horses admitted for colic during a one-year period. Blood gas, pH, electrolyte (K +, Na+, Ca++, Cl-), glucose and lactate values were determined for blood and peritoneal fluid samples; other values recorded for peritoneal fluid included gross appearance, total protein and nucleated cell count. Information regarding diagnosis, treatment and outcome was retrieved from the medical records. Results: Peritoneal and plasma levels of lactate were lower in control compared to clinical cases. Horses with ISSO had a higher peritoneal lactate value (8.45 mmol/l) than those with nonstrangulating obstruction (2.09 mmol/l). Factors with the strongest correlations with the presence of ISSO were changes in the gross appearance of the peritoneal fluid and values of peritoneal fluid chloride, pH and log 10 lactate. Conclusions: Analysis of peritoneal fluid gross appearance, pH, lactate and chloride can be used for diagnosis of ISSO. Potential relevance: Peritoneal fluid lactate is a better predictor of ISSO than blood lactate and may aid in early detection of catastrophic peritoneal lesions such as intestinal strangulation and rupture.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalEquine Veterinary Journal
Volume37
Issue number4
StatePublished - Jul 2005

Fingerprint

Colic
Ascitic Fluid
colic
ischemia
Horses
lactates
Lactic Acid
Ischemia
horses
blood
lesions (animal)
Chlorides
chlorides
fluids
blood gases
Electrolytes
electrolytes
Medical Records
Rupture
Cause of Death

Keywords

  • Abdominocentesis
  • Colic
  • Equine
  • Horse
  • Intestinal ischaemia
  • Lactate

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic. / Latson, K. M.; Nieto, Jorge; Beldomenico, P. M.; Snyder, J. R.

In: Equine Veterinary Journal, Vol. 37, No. 4, 07.2005, p. 342-346.

Research output: Contribution to journalArticle

Latson, K. M. ; Nieto, Jorge ; Beldomenico, P. M. ; Snyder, J. R. / Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic. In: Equine Veterinary Journal. 2005 ; Vol. 37, No. 4. pp. 342-346.
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