Evaluation of myocardial uptake of (99m)technetium pyrophosphate in clinical exercise induced ventricular ischemia

D. S. Berman, A. F. Salel, E. A. Amsterdam, G. L. DeNardo, D. T. Mason

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Although acute infarction of the myocardium is known to accumulate 99m technetium pyrophosphate, it is not entirely clear that ischemia alone without necrosis does not result in abnormal uptake of 99m technetium pyrophosphate. The present study investigates whether transient myocardial ischemia is associated with localization of 99m technetium pyrophosphate by evaluating images obtained with the scintillation camera at rest and after exercise in 15 patients with unequivocal myocardial ischemia. All patients had angina pectoris, multivessel coronary artery stenoses by selective arteriographic studies, and electrocardiographic ischemic responses on treadmill exercise. Eleven of the 15 patients also underwent radionuclide imaging with 81rubidium at rest and after exercise; the results demonstrated scintigraphic ischemia. The scintiscans with 99m technetium pyrophosphate revealed no evidence of increased myocardial radioactivity after exercise compared to rest in 14 of the 15 patients. In contrast, myocardial activity was observed with 99m technetium pyrophosphate after treadmill exertion in the remaining patient, in whom a small subendocardial infarction appeared to have occurred with the exercise. It is concluded from these results that transient myocardial ischemia does not cause localization of 99m technetium pyrophosphate. These findings support the specificity of abnormal localization of 99m technetium pyrophosphate for acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
Issue number3
StatePublished - 1977

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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