Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury

Gene G Gurkoff, Jennifer D. Gahan, Rahil T. Ghiasvand, Michael R. Hunsaker, Ken Van, Jun Feng Feng, Kiarash Shahlaie, Robert F Berman, Bruce G Lyeth, Michael M. Folkerts

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Impairments in learning and memory occur in as many as 50% of patients following traumatic brain injury (TBI). Similar impairments occur in rodent models of TBI, and the development of new memory testing procedures provides an opportunity to examine how TBI affects memory processing in specific neural memory systems. Specifically, metric, topological, and temporal ordering tasks are object-based tests for memory of spatial orientation and temporal sequencing working memory developed for use in rodents. Previous studies demonstrated that specific lesions of the dentate gyrus/CA3 of the hippocampus and the parietal cortex resulted in deficits in the metric and topological spatial orientation tasks, respectively. Lesions of the CA1 impaired a rat's ability to recall the temporal order of odors. The purpose of the following study was to determine whether moderate lateral fluid percussion TBI would generate deficits in these working memory tasks, and whether observed deficits were associated with cell loss in the CA2/3 and/or CA1 of the hippocampus. Two weeks following a moderate lateral fluid percussion TBI, adult rats demonstrated significant deficits in both the metric and temporal ordering tasks (p<0.05) but not in the topological task. Stereological analysis identified a significant reduction in neurons in the CA2/3 (p<0.05) but not the CA1 of the hippocampus. These data demonstrate the utility of three object-based tasks to expand our understanding of how different neural memory systems are affected by TBI.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalJournal of Neurotrauma
Volume30
Issue number4
DOIs
StatePublished - Feb 15 2013

Fingerprint

Percussion
Wounds and Injuries
Short-Term Memory
Rodentia
Hippocampus
Parahippocampal Gyrus
Parietal Lobe
Aptitude
Dentate Gyrus
Traumatic Brain Injury
Learning
Neurons

Keywords

  • anatomical specificity
  • cognitive dysfunction
  • hippocampus
  • TBI
  • working memory

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Gurkoff, G. G., Gahan, J. D., Ghiasvand, R. T., Hunsaker, M. R., Van, K., Feng, J. F., ... Folkerts, M. M. (2013). Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury. Journal of Neurotrauma, 30(4), 292-300. https://doi.org/10.1089/neu.2012.2463

Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury. / Gurkoff, Gene G; Gahan, Jennifer D.; Ghiasvand, Rahil T.; Hunsaker, Michael R.; Van, Ken; Feng, Jun Feng; Shahlaie, Kiarash; Berman, Robert F; Lyeth, Bruce G; Folkerts, Michael M.

In: Journal of Neurotrauma, Vol. 30, No. 4, 15.02.2013, p. 292-300.

Research output: Contribution to journalArticle

Gurkoff, Gene G ; Gahan, Jennifer D. ; Ghiasvand, Rahil T. ; Hunsaker, Michael R. ; Van, Ken ; Feng, Jun Feng ; Shahlaie, Kiarash ; Berman, Robert F ; Lyeth, Bruce G ; Folkerts, Michael M. / Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury. In: Journal of Neurotrauma. 2013 ; Vol. 30, No. 4. pp. 292-300.
@article{70a7ae5494154e66bb103547922e30dc,
title = "Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury",
abstract = "Impairments in learning and memory occur in as many as 50{\%} of patients following traumatic brain injury (TBI). Similar impairments occur in rodent models of TBI, and the development of new memory testing procedures provides an opportunity to examine how TBI affects memory processing in specific neural memory systems. Specifically, metric, topological, and temporal ordering tasks are object-based tests for memory of spatial orientation and temporal sequencing working memory developed for use in rodents. Previous studies demonstrated that specific lesions of the dentate gyrus/CA3 of the hippocampus and the parietal cortex resulted in deficits in the metric and topological spatial orientation tasks, respectively. Lesions of the CA1 impaired a rat's ability to recall the temporal order of odors. The purpose of the following study was to determine whether moderate lateral fluid percussion TBI would generate deficits in these working memory tasks, and whether observed deficits were associated with cell loss in the CA2/3 and/or CA1 of the hippocampus. Two weeks following a moderate lateral fluid percussion TBI, adult rats demonstrated significant deficits in both the metric and temporal ordering tasks (p<0.05) but not in the topological task. Stereological analysis identified a significant reduction in neurons in the CA2/3 (p<0.05) but not the CA1 of the hippocampus. These data demonstrate the utility of three object-based tasks to expand our understanding of how different neural memory systems are affected by TBI.",
keywords = "anatomical specificity, cognitive dysfunction, hippocampus, TBI, working memory",
author = "Gurkoff, {Gene G} and Gahan, {Jennifer D.} and Ghiasvand, {Rahil T.} and Hunsaker, {Michael R.} and Ken Van and Feng, {Jun Feng} and Kiarash Shahlaie and Berman, {Robert F} and Lyeth, {Bruce G} and Folkerts, {Michael M.}",
year = "2013",
month = "2",
day = "15",
doi = "10.1089/neu.2012.2463",
language = "English (US)",
volume = "30",
pages = "292--300",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury

AU - Gurkoff, Gene G

AU - Gahan, Jennifer D.

AU - Ghiasvand, Rahil T.

AU - Hunsaker, Michael R.

AU - Van, Ken

AU - Feng, Jun Feng

AU - Shahlaie, Kiarash

AU - Berman, Robert F

AU - Lyeth, Bruce G

AU - Folkerts, Michael M.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Impairments in learning and memory occur in as many as 50% of patients following traumatic brain injury (TBI). Similar impairments occur in rodent models of TBI, and the development of new memory testing procedures provides an opportunity to examine how TBI affects memory processing in specific neural memory systems. Specifically, metric, topological, and temporal ordering tasks are object-based tests for memory of spatial orientation and temporal sequencing working memory developed for use in rodents. Previous studies demonstrated that specific lesions of the dentate gyrus/CA3 of the hippocampus and the parietal cortex resulted in deficits in the metric and topological spatial orientation tasks, respectively. Lesions of the CA1 impaired a rat's ability to recall the temporal order of odors. The purpose of the following study was to determine whether moderate lateral fluid percussion TBI would generate deficits in these working memory tasks, and whether observed deficits were associated with cell loss in the CA2/3 and/or CA1 of the hippocampus. Two weeks following a moderate lateral fluid percussion TBI, adult rats demonstrated significant deficits in both the metric and temporal ordering tasks (p<0.05) but not in the topological task. Stereological analysis identified a significant reduction in neurons in the CA2/3 (p<0.05) but not the CA1 of the hippocampus. These data demonstrate the utility of three object-based tasks to expand our understanding of how different neural memory systems are affected by TBI.

AB - Impairments in learning and memory occur in as many as 50% of patients following traumatic brain injury (TBI). Similar impairments occur in rodent models of TBI, and the development of new memory testing procedures provides an opportunity to examine how TBI affects memory processing in specific neural memory systems. Specifically, metric, topological, and temporal ordering tasks are object-based tests for memory of spatial orientation and temporal sequencing working memory developed for use in rodents. Previous studies demonstrated that specific lesions of the dentate gyrus/CA3 of the hippocampus and the parietal cortex resulted in deficits in the metric and topological spatial orientation tasks, respectively. Lesions of the CA1 impaired a rat's ability to recall the temporal order of odors. The purpose of the following study was to determine whether moderate lateral fluid percussion TBI would generate deficits in these working memory tasks, and whether observed deficits were associated with cell loss in the CA2/3 and/or CA1 of the hippocampus. Two weeks following a moderate lateral fluid percussion TBI, adult rats demonstrated significant deficits in both the metric and temporal ordering tasks (p<0.05) but not in the topological task. Stereological analysis identified a significant reduction in neurons in the CA2/3 (p<0.05) but not the CA1 of the hippocampus. These data demonstrate the utility of three object-based tasks to expand our understanding of how different neural memory systems are affected by TBI.

KW - anatomical specificity

KW - cognitive dysfunction

KW - hippocampus

KW - TBI

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=84874028177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874028177&partnerID=8YFLogxK

U2 - 10.1089/neu.2012.2463

DO - 10.1089/neu.2012.2463

M3 - Article

C2 - 23140483

AN - SCOPUS:84874028177

VL - 30

SP - 292

EP - 300

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 4

ER -