Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI

Jaakko J. Hartiala, Elyse Foster, Naoya Fujita, Gerhard H. Mostbeck, Gary R Caputo, Gary P. Fazio, Timothy Winslow, Charles B. Higgins

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Velocity-encoded cine MRI (VEC-MRI) can measure volume flow at specified sites in the heart. This study used VEC-MRI to measure flow across the mitral valve to compare the contribution of atrial systole to left atrial filling in normal subjects and patients with left ventricular hypertrophy. The study population consisted of 12 normal subjects (mean age 34.5 years) and nine patients with various degrees of left ventricular hypertrophy resulting from aortic stenosis (mean age 70 years). VEC-MRI was performed in double-oblique planes through the heart to measure both the mitral inflow velocity pattern ( E A ratio) and the volumetric flow across the mitral valve. The left atrial contribution to left ventricular filling (AC%) was calculated. The results were compared with Doppler echocardiographic parameters. The VEC-MRI-derived mitral E A ratios showed a significant linear correlation with E A ratios calculated from Doppler echocardiography (r = 0.94), and the VEC-MRI-derived E A ratios (2.1 ± 0.5 vs 1.0 ± 0.4) and AC% values (24.9 ± 7.2 vs 45.7 ± 16.4) were significantly different between normal subjects and patients with aortic stenosis (p < 0.01 in both groups). The same differences were seen in the Doppler echocardiographic parameters. The VEC-MRI-derived E A ratio and AC% showed significant hyperbolic and linear correlations with left ventricular mass indexes (r = 0.95 and 0.86). In addition, the VEC-MRI-determined E A ratio and the volumetric AC% displayed a highly significant hyperbolic correlation (r = 0.95). Thus VEC-MRI can be used to evaluate left ventricular diastolic filling characteristics in normal subjects and patients with abnormalities of diastolic filling.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalAmerican Heart Journal
Volume127
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Cine Magnetic Resonance Imaging
Aortic Valve Stenosis
Left Ventricular Hypertrophy
Mitral Valve
Doppler Echocardiography
Systole

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI. / Hartiala, Jaakko J.; Foster, Elyse; Fujita, Naoya; Mostbeck, Gerhard H.; Caputo, Gary R; Fazio, Gary P.; Winslow, Timothy; Higgins, Charles B.

In: American Heart Journal, Vol. 127, No. 3, 1994, p. 593-600.

Research output: Contribution to journalArticle

Hartiala, JJ, Foster, E, Fujita, N, Mostbeck, GH, Caputo, GR, Fazio, GP, Winslow, T & Higgins, CB 1994, 'Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI', American Heart Journal, vol. 127, no. 3, pp. 593-600. https://doi.org/10.1016/0002-8703(94)90668-8
Hartiala, Jaakko J. ; Foster, Elyse ; Fujita, Naoya ; Mostbeck, Gerhard H. ; Caputo, Gary R ; Fazio, Gary P. ; Winslow, Timothy ; Higgins, Charles B. / Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI. In: American Heart Journal. 1994 ; Vol. 127, No. 3. pp. 593-600.
@article{912d30df34954f28af572f9f73fe0b2e,
title = "Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI",
abstract = "Velocity-encoded cine MRI (VEC-MRI) can measure volume flow at specified sites in the heart. This study used VEC-MRI to measure flow across the mitral valve to compare the contribution of atrial systole to left atrial filling in normal subjects and patients with left ventricular hypertrophy. The study population consisted of 12 normal subjects (mean age 34.5 years) and nine patients with various degrees of left ventricular hypertrophy resulting from aortic stenosis (mean age 70 years). VEC-MRI was performed in double-oblique planes through the heart to measure both the mitral inflow velocity pattern ( E A ratio) and the volumetric flow across the mitral valve. The left atrial contribution to left ventricular filling (AC{\%}) was calculated. The results were compared with Doppler echocardiographic parameters. The VEC-MRI-derived mitral E A ratios showed a significant linear correlation with E A ratios calculated from Doppler echocardiography (r = 0.94), and the VEC-MRI-derived E A ratios (2.1 ± 0.5 vs 1.0 ± 0.4) and AC{\%} values (24.9 ± 7.2 vs 45.7 ± 16.4) were significantly different between normal subjects and patients with aortic stenosis (p < 0.01 in both groups). The same differences were seen in the Doppler echocardiographic parameters. The VEC-MRI-derived E A ratio and AC{\%} showed significant hyperbolic and linear correlations with left ventricular mass indexes (r = 0.95 and 0.86). In addition, the VEC-MRI-determined E A ratio and the volumetric AC{\%} displayed a highly significant hyperbolic correlation (r = 0.95). Thus VEC-MRI can be used to evaluate left ventricular diastolic filling characteristics in normal subjects and patients with abnormalities of diastolic filling.",
author = "Hartiala, {Jaakko J.} and Elyse Foster and Naoya Fujita and Mostbeck, {Gerhard H.} and Caputo, {Gary R} and Fazio, {Gary P.} and Timothy Winslow and Higgins, {Charles B.}",
year = "1994",
doi = "10.1016/0002-8703(94)90668-8",
language = "English (US)",
volume = "127",
pages = "593--600",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Evaluation of left atrial contribution to left ventricular filling in aortic stenosis by velocity-encoded cine MRI

AU - Hartiala, Jaakko J.

AU - Foster, Elyse

AU - Fujita, Naoya

AU - Mostbeck, Gerhard H.

AU - Caputo, Gary R

AU - Fazio, Gary P.

AU - Winslow, Timothy

AU - Higgins, Charles B.

PY - 1994

Y1 - 1994

N2 - Velocity-encoded cine MRI (VEC-MRI) can measure volume flow at specified sites in the heart. This study used VEC-MRI to measure flow across the mitral valve to compare the contribution of atrial systole to left atrial filling in normal subjects and patients with left ventricular hypertrophy. The study population consisted of 12 normal subjects (mean age 34.5 years) and nine patients with various degrees of left ventricular hypertrophy resulting from aortic stenosis (mean age 70 years). VEC-MRI was performed in double-oblique planes through the heart to measure both the mitral inflow velocity pattern ( E A ratio) and the volumetric flow across the mitral valve. The left atrial contribution to left ventricular filling (AC%) was calculated. The results were compared with Doppler echocardiographic parameters. The VEC-MRI-derived mitral E A ratios showed a significant linear correlation with E A ratios calculated from Doppler echocardiography (r = 0.94), and the VEC-MRI-derived E A ratios (2.1 ± 0.5 vs 1.0 ± 0.4) and AC% values (24.9 ± 7.2 vs 45.7 ± 16.4) were significantly different between normal subjects and patients with aortic stenosis (p < 0.01 in both groups). The same differences were seen in the Doppler echocardiographic parameters. The VEC-MRI-derived E A ratio and AC% showed significant hyperbolic and linear correlations with left ventricular mass indexes (r = 0.95 and 0.86). In addition, the VEC-MRI-determined E A ratio and the volumetric AC% displayed a highly significant hyperbolic correlation (r = 0.95). Thus VEC-MRI can be used to evaluate left ventricular diastolic filling characteristics in normal subjects and patients with abnormalities of diastolic filling.

AB - Velocity-encoded cine MRI (VEC-MRI) can measure volume flow at specified sites in the heart. This study used VEC-MRI to measure flow across the mitral valve to compare the contribution of atrial systole to left atrial filling in normal subjects and patients with left ventricular hypertrophy. The study population consisted of 12 normal subjects (mean age 34.5 years) and nine patients with various degrees of left ventricular hypertrophy resulting from aortic stenosis (mean age 70 years). VEC-MRI was performed in double-oblique planes through the heart to measure both the mitral inflow velocity pattern ( E A ratio) and the volumetric flow across the mitral valve. The left atrial contribution to left ventricular filling (AC%) was calculated. The results were compared with Doppler echocardiographic parameters. The VEC-MRI-derived mitral E A ratios showed a significant linear correlation with E A ratios calculated from Doppler echocardiography (r = 0.94), and the VEC-MRI-derived E A ratios (2.1 ± 0.5 vs 1.0 ± 0.4) and AC% values (24.9 ± 7.2 vs 45.7 ± 16.4) were significantly different between normal subjects and patients with aortic stenosis (p < 0.01 in both groups). The same differences were seen in the Doppler echocardiographic parameters. The VEC-MRI-derived E A ratio and AC% showed significant hyperbolic and linear correlations with left ventricular mass indexes (r = 0.95 and 0.86). In addition, the VEC-MRI-determined E A ratio and the volumetric AC% displayed a highly significant hyperbolic correlation (r = 0.95). Thus VEC-MRI can be used to evaluate left ventricular diastolic filling characteristics in normal subjects and patients with abnormalities of diastolic filling.

UR - http://www.scopus.com/inward/record.url?scp=0028266848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028266848&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(94)90668-8

DO - 10.1016/0002-8703(94)90668-8

M3 - Article

VL - 127

SP - 593

EP - 600

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 3

ER -