Abstract
The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 385-390 |
| Number of pages | 6 |
| Journal | Veterinary Dermatology |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2008 |
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ASJC Scopus subject areas
- veterinary(all)
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Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse. / Hilton, Hugo; Affolter, Verena K; White, Stephen D.
In: Veterinary Dermatology, Vol. 19, No. 6, 12.2008, p. 385-390.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse
AU - Hilton, Hugo
AU - Affolter, Verena K
AU - White, Stephen D
PY - 2008/12
Y1 - 2008/12
N2 - The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.
AB - The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.
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UR - http://www.scopus.com/inward/citedby.url?scp=57349199356&partnerID=8YFLogxK
U2 - 10.1111/j.1365-3164.2008.00715.x
DO - 10.1111/j.1365-3164.2008.00715.x
M3 - Article
C2 - 19055613
AN - SCOPUS:57349199356
VL - 19
SP - 385
EP - 390
JO - Veterinary Dermatology
JF - Veterinary Dermatology
SN - 0959-4493
IS - 6
ER -