Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalVeterinary Dermatology
Volume19
Issue number6
DOIs
StatePublished - Dec 2008

Fingerprint

Emollients
hyperkeratosis
phytosphingosine
Tacrolimus
Ointments
tacrolimus
Horses
ointments
horses
histopathology
Water
Keratins
Cornea
Extremities
keratin
Gels
cornea
mares
pretreatment
water

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse. / Hilton, Hugo; Affolter, Verena K; White, Stephen D.

In: Veterinary Dermatology, Vol. 19, No. 6, 12.2008, p. 385-390.

Research output: Contribution to journalArticle

@article{dede3088880548e5ad17d3012b5b0cc7,
title = "Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse",
abstract = "The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1{\%} tacrolimus ointment, 0.1{\%} adapalene gel, 0.2{\%} phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1{\%} tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.",
author = "Hugo Hilton and Affolter, {Verena K} and White, {Stephen D}",
year = "2008",
month = "12",
doi = "10.1111/j.1365-3164.2008.00715.x",
language = "English (US)",
volume = "19",
pages = "385--390",
journal = "Veterinary Dermatology",
issn = "0959-4493",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse

AU - Hilton, Hugo

AU - Affolter, Verena K

AU - White, Stephen D

PY - 2008/12

Y1 - 2008/12

N2 - The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.

AB - The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.

UR - http://www.scopus.com/inward/record.url?scp=57349199356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57349199356&partnerID=8YFLogxK

U2 - 10.1111/j.1365-3164.2008.00715.x

DO - 10.1111/j.1365-3164.2008.00715.x

M3 - Article

C2 - 19055613

AN - SCOPUS:57349199356

VL - 19

SP - 385

EP - 390

JO - Veterinary Dermatology

JF - Veterinary Dermatology

SN - 0959-4493

IS - 6

ER -