Evaluation of four biodegradable, injectable bone cements in an experimental drill hole model in sheep

Brigitte Von Rechenberg, Oliver R. Génot, Katja Nuss, Larry D Galuppo, Mark Fulmer, Evan Jacobson, Peter Kronen, Kati Zlinszky, Jörg A. Auer

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.

Original languageEnglish (US)
Pages (from-to)130-138
Number of pages9
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Issue number1
StatePublished - Sep 2013


  • Bone cements
  • Bone substitute
  • Calcium phosphate cements
  • Injectable cements
  • Synthetic cements

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science


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