Abstract
Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 130-138 |
| Number of pages | 9 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 85 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 2013 |
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Keywords
- Bone cements
- Bone substitute
- Calcium phosphate cements
- Injectable cements
- Synthetic cements
ASJC Scopus subject areas
- Biotechnology
- Pharmaceutical Science
Cite this
Evaluation of four biodegradable, injectable bone cements in an experimental drill hole model in sheep. / Von Rechenberg, Brigitte; Génot, Oliver R.; Nuss, Katja; Galuppo, Larry D; Fulmer, Mark; Jacobson, Evan; Kronen, Peter; Zlinszky, Kati; Auer, Jörg A.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 1, 09.2013, p. 130-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of four biodegradable, injectable bone cements in an experimental drill hole model in sheep
AU - Von Rechenberg, Brigitte
AU - Génot, Oliver R.
AU - Nuss, Katja
AU - Galuppo, Larry D
AU - Fulmer, Mark
AU - Jacobson, Evan
AU - Kronen, Peter
AU - Zlinszky, Kati
AU - Auer, Jörg A.
PY - 2013/9
Y1 - 2013/9
N2 - Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.
AB - Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.
KW - Bone cements
KW - Bone substitute
KW - Calcium phosphate cements
KW - Injectable cements
KW - Synthetic cements
UR - http://www.scopus.com/inward/record.url?scp=84882891416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882891416&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2013.04.013
DO - 10.1016/j.ejpb.2013.04.013
M3 - Article
C2 - 23680585
AN - SCOPUS:84882891416
VL - 85
SP - 130
EP - 138
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
IS - 1
ER -