Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers

Tobias J. Moritz, Christopher R Polage, Douglas S. Taylor, Denise M. Krol, Stephen M. Lane, James W Chan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Laser tweezers Raman spectroscopy was used to detect the cellular response of Escherichia coli cells to penicillin G-streptomycin and cefazolin. Time-dependent intensity changes of several Raman peaks at 729, 1,245, and 1,660 cm-1 enabled untreated cells and cells treated with the different antibiotic drugs to be distinguished.

Original languageEnglish (US)
Pages (from-to)4287-4290
Number of pages4
JournalJournal of Clinical Microbiology
Volume48
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Optical Tweezers
Raman Spectrum Analysis
Escherichia coli
Anti-Bacterial Agents
Cefazolin
Penicillin G
Streptomycin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers. / Moritz, Tobias J.; Polage, Christopher R; Taylor, Douglas S.; Krol, Denise M.; Lane, Stephen M.; Chan, James W.

In: Journal of Clinical Microbiology, Vol. 48, No. 11, 11.2010, p. 4287-4290.

Research output: Contribution to journalArticle

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