Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers

Tobias J. Moritz, Christopher R Polage, Douglas S. Taylor, Denise M. Krol, Stephen M. Lane, James W Chan

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Laser tweezers Raman spectroscopy was used to detect the cellular response of Escherichia coli cells to penicillin G-streptomycin and cefazolin. Time-dependent intensity changes of several Raman peaks at 729, 1,245, and 1,660 cm-1 enabled untreated cells and cells treated with the different antibiotic drugs to be distinguished.

Original languageEnglish (US)
Pages (from-to)4287-4290
Number of pages4
JournalJournal of Clinical Microbiology
Volume48
Issue number11
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Microbiology (medical)

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