Evaluation of efficacy of an automated single-voxel proton MRS algorithm on a 3T system

Masaki Ohkubo, Teruo Kimura, Hitoshi Matsuzawa, Tsuyoshi Matsuda, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To evaluate the efficacy of a fully automatic, single-voxel, proton MR spectroscopy algorithm on a 3.0T MR system. Methods: The PROBE/SVQ algorithm (GE Medical Systems) was evaluated on a General Electric (GE) Signa LX-3T system. Ten normal volunteers (female, 21.1±2.0 years old) participated in the study. Nine representative regions of interest were examined, namely, right and left frontal white matter; right and left parietal white matter; right and left basal ganglia; right and left dentate nucleus; and pons. Results: The mean coefficients of variation in all regions for the N-acetyl-aspartate to creatine ratio (NAA/Cr), choline to creatine ratio (Cho/Cr), and choline to N-acetyl-aspartate ratio (Cho/NAA) were 10.2±2.4%, 11.4±3.2% and 12.6±1.4%, respectively. Conclusion: A fully automated spectroscopic examination under clinical setting utilizing the PROBE/SVQ algorithm appears to be a reliable method, extending the window of routine clinical assessment of brain metabolism.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalMagnetic Resonance in Medical Sciences
Issue number2
StatePublished - 2002


  • 3T
  • Automation
  • Magnetic resonance spectroscopy (MRS)
  • Proton MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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