Evaluation of continuous infusion of lidocaine on gastrointestinal tract function in normal horses

Karen E. Rusiecki, Jorge Nieto, Sarah M. Puchalski, Jack R. Snyder

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective - To determine the effect of continuous infusion of lidocaine on fecal transit time in normal horses. Study Design - Experimental randomized cross-over study. Animals - Healthy horses (n=6). Methods - Barium-filled microspheres were administered to horses by nasogastric intubation and feces were collected every 2 hours for 4 days. A bolus of 2% lidocaine (1.3 mg/kg) was administered randomly, followed by a continuous infusion of lidocaine (0.05 mg/kg/min) for 3 days or an equivalent volume of saline. The washout period was 10 days. Variables assessed included defecation frequency, weight of feces produced, intestinal transit time (number of microspheres observed on radiographs), fecal moisture content, borborygmus score, heart and respiratory rate, and signs of lidocaine toxicity (e.g., ataxia, CNS depression). Results - During the first 24 hours of lidocaine administration, mean (±SD) fecal output (10.8±6.9 kg) was decreased compared with controls (15±4.9 kg). Mean (±SEM) time for passing 50% of the barium-filled microspheres was shorter in controls (42±1.13 hours) compared with the lidocaine group (50±1.32 hours). Conclusions - Continuous infusion of lidocaine increases the transit time of feces in normal horses. Clinical Relevance - Clinicians need to be aware of the effects of using a continuous infusion of lidocaine on the transit time of feces in normal horses, with a potential for exacerbating those effects when combined with drugs that decrease motility and in horses with medical colic (e.g., impaction) or where a diagnosis has not been made.

Original languageEnglish (US)
Pages (from-to)564-570
Number of pages7
JournalVeterinary Surgery
Volume37
Issue number6
DOIs
StatePublished - Aug 2008

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lidocaine
Lidocaine
Horses
gastrointestinal system
Gastrointestinal Tract
horses
Feces
feces
Microspheres
barium
Barium
Gastrointestinal Intubation
gastrointestinal transit
Defecation
defecation
Colic
colic
enteral feeding
Ataxia
Respiratory Rate

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of continuous infusion of lidocaine on gastrointestinal tract function in normal horses. / Rusiecki, Karen E.; Nieto, Jorge; Puchalski, Sarah M.; Snyder, Jack R.

In: Veterinary Surgery, Vol. 37, No. 6, 08.2008, p. 564-570.

Research output: Contribution to journalArticle

Rusiecki, Karen E. ; Nieto, Jorge ; Puchalski, Sarah M. ; Snyder, Jack R. / Evaluation of continuous infusion of lidocaine on gastrointestinal tract function in normal horses. In: Veterinary Surgery. 2008 ; Vol. 37, No. 6. pp. 564-570.
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abstract = "Objective - To determine the effect of continuous infusion of lidocaine on fecal transit time in normal horses. Study Design - Experimental randomized cross-over study. Animals - Healthy horses (n=6). Methods - Barium-filled microspheres were administered to horses by nasogastric intubation and feces were collected every 2 hours for 4 days. A bolus of 2{\%} lidocaine (1.3 mg/kg) was administered randomly, followed by a continuous infusion of lidocaine (0.05 mg/kg/min) for 3 days or an equivalent volume of saline. The washout period was 10 days. Variables assessed included defecation frequency, weight of feces produced, intestinal transit time (number of microspheres observed on radiographs), fecal moisture content, borborygmus score, heart and respiratory rate, and signs of lidocaine toxicity (e.g., ataxia, CNS depression). Results - During the first 24 hours of lidocaine administration, mean (±SD) fecal output (10.8±6.9 kg) was decreased compared with controls (15±4.9 kg). Mean (±SEM) time for passing 50{\%} of the barium-filled microspheres was shorter in controls (42±1.13 hours) compared with the lidocaine group (50±1.32 hours). Conclusions - Continuous infusion of lidocaine increases the transit time of feces in normal horses. Clinical Relevance - Clinicians need to be aware of the effects of using a continuous infusion of lidocaine on the transit time of feces in normal horses, with a potential for exacerbating those effects when combined with drugs that decrease motility and in horses with medical colic (e.g., impaction) or where a diagnosis has not been made.",
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