Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.

E. Zenger, W. C. Brown, W. Song, A. M. Wolf, Niels C Pedersen, M. Longnecker, J. Li, E. W. Collisson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although feline immunodeficiency virus (FIV) and the unrelated retrovirus feline leukemia virus (FeLV) are associated with acquired immune deficiency in cats, experimental and field evidence indicates that coinfection with both viruses may lead to more serious disease syndrome. A third feline retrovirus, feline syncytium-forming virus (FeSFV), which is far more prevalent than either FIV or FeLV and is considered nonpathogenic in nature, is consistently coisolated from sick, FIV-infected cats. To determine the potential role of FeSFV in enhancement of FIV-mediated disease, persistent FeSFV infection was established in 14 of 24 nine-month-old cats. Four months later, half the FeSFV-infected and half the noninfected cats were inoculated with blood obtained from a cat persistently infected with the Petaluma strain of FIV. At postinoculation week 17, 1 male cat infected with only FIV died of bacterial bronchopneumonia that could have been attributed to FIV-induced acquired immune deficiency-like syndrome. However, none of the remaining cats had clinical illness, whether infected with either virus alone or coinfected with both viruses. As early as postinoculation week 6, decreases were observed in the CD4+ to CD8+ T-lymphocyte ratio of both groups of cats inoculated with FIV. Infection with FeSFV had no effect on the CD4+ to CD8+ T-cell ratio. Mitogen stimulation assays and total WBC count were unaffected by FeSFV infection, although an increase in numbers of neutrophils from FeSFV-infected cats was consistent, especially when compared with the decrease observed after FIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume54
Issue number5
StatePublished - May 1993
Externally publishedYes

Fingerprint

Spumavirus
Feline Immunodeficiency Virus
Feline immunodeficiency virus
giant cells
Virus Diseases
Cats
cats
viruses
infection
Feline Leukemia Virus
Retroviridae
Viruses
T-Lymphocytes
Feline leukemia virus
Bronchopneumonia
immunosuppression
Felidae
Coinfection
Mitogens
T-lymphocytes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Zenger, E., Brown, W. C., Song, W., Wolf, A. M., Pedersen, N. C., Longnecker, M., ... Collisson, E. W. (1993). Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection. American Journal of Veterinary Research, 54(5), 713-718.

Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection. / Zenger, E.; Brown, W. C.; Song, W.; Wolf, A. M.; Pedersen, Niels C; Longnecker, M.; Li, J.; Collisson, E. W.

In: American Journal of Veterinary Research, Vol. 54, No. 5, 05.1993, p. 713-718.

Research output: Contribution to journalArticle

Zenger, E, Brown, WC, Song, W, Wolf, AM, Pedersen, NC, Longnecker, M, Li, J & Collisson, EW 1993, 'Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.', American Journal of Veterinary Research, vol. 54, no. 5, pp. 713-718.
Zenger, E. ; Brown, W. C. ; Song, W. ; Wolf, A. M. ; Pedersen, Niels C ; Longnecker, M. ; Li, J. ; Collisson, E. W. / Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection. In: American Journal of Veterinary Research. 1993 ; Vol. 54, No. 5. pp. 713-718.
@article{6eb0370e5f8446b4868a2e115b48bdfa,
title = "Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.",
abstract = "Although feline immunodeficiency virus (FIV) and the unrelated retrovirus feline leukemia virus (FeLV) are associated with acquired immune deficiency in cats, experimental and field evidence indicates that coinfection with both viruses may lead to more serious disease syndrome. A third feline retrovirus, feline syncytium-forming virus (FeSFV), which is far more prevalent than either FIV or FeLV and is considered nonpathogenic in nature, is consistently coisolated from sick, FIV-infected cats. To determine the potential role of FeSFV in enhancement of FIV-mediated disease, persistent FeSFV infection was established in 14 of 24 nine-month-old cats. Four months later, half the FeSFV-infected and half the noninfected cats were inoculated with blood obtained from a cat persistently infected with the Petaluma strain of FIV. At postinoculation week 17, 1 male cat infected with only FIV died of bacterial bronchopneumonia that could have been attributed to FIV-induced acquired immune deficiency-like syndrome. However, none of the remaining cats had clinical illness, whether infected with either virus alone or coinfected with both viruses. As early as postinoculation week 6, decreases were observed in the CD4+ to CD8+ T-lymphocyte ratio of both groups of cats inoculated with FIV. Infection with FeSFV had no effect on the CD4+ to CD8+ T-cell ratio. Mitogen stimulation assays and total WBC count were unaffected by FeSFV infection, although an increase in numbers of neutrophils from FeSFV-infected cats was consistent, especially when compared with the decrease observed after FIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "E. Zenger and Brown, {W. C.} and W. Song and Wolf, {A. M.} and Pedersen, {Niels C} and M. Longnecker and J. Li and Collisson, {E. W.}",
year = "1993",
month = "5",
language = "English (US)",
volume = "54",
pages = "713--718",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "5",

}

TY - JOUR

T1 - Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.

AU - Zenger, E.

AU - Brown, W. C.

AU - Song, W.

AU - Wolf, A. M.

AU - Pedersen, Niels C

AU - Longnecker, M.

AU - Li, J.

AU - Collisson, E. W.

PY - 1993/5

Y1 - 1993/5

N2 - Although feline immunodeficiency virus (FIV) and the unrelated retrovirus feline leukemia virus (FeLV) are associated with acquired immune deficiency in cats, experimental and field evidence indicates that coinfection with both viruses may lead to more serious disease syndrome. A third feline retrovirus, feline syncytium-forming virus (FeSFV), which is far more prevalent than either FIV or FeLV and is considered nonpathogenic in nature, is consistently coisolated from sick, FIV-infected cats. To determine the potential role of FeSFV in enhancement of FIV-mediated disease, persistent FeSFV infection was established in 14 of 24 nine-month-old cats. Four months later, half the FeSFV-infected and half the noninfected cats were inoculated with blood obtained from a cat persistently infected with the Petaluma strain of FIV. At postinoculation week 17, 1 male cat infected with only FIV died of bacterial bronchopneumonia that could have been attributed to FIV-induced acquired immune deficiency-like syndrome. However, none of the remaining cats had clinical illness, whether infected with either virus alone or coinfected with both viruses. As early as postinoculation week 6, decreases were observed in the CD4+ to CD8+ T-lymphocyte ratio of both groups of cats inoculated with FIV. Infection with FeSFV had no effect on the CD4+ to CD8+ T-cell ratio. Mitogen stimulation assays and total WBC count were unaffected by FeSFV infection, although an increase in numbers of neutrophils from FeSFV-infected cats was consistent, especially when compared with the decrease observed after FIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Although feline immunodeficiency virus (FIV) and the unrelated retrovirus feline leukemia virus (FeLV) are associated with acquired immune deficiency in cats, experimental and field evidence indicates that coinfection with both viruses may lead to more serious disease syndrome. A third feline retrovirus, feline syncytium-forming virus (FeSFV), which is far more prevalent than either FIV or FeLV and is considered nonpathogenic in nature, is consistently coisolated from sick, FIV-infected cats. To determine the potential role of FeSFV in enhancement of FIV-mediated disease, persistent FeSFV infection was established in 14 of 24 nine-month-old cats. Four months later, half the FeSFV-infected and half the noninfected cats were inoculated with blood obtained from a cat persistently infected with the Petaluma strain of FIV. At postinoculation week 17, 1 male cat infected with only FIV died of bacterial bronchopneumonia that could have been attributed to FIV-induced acquired immune deficiency-like syndrome. However, none of the remaining cats had clinical illness, whether infected with either virus alone or coinfected with both viruses. As early as postinoculation week 6, decreases were observed in the CD4+ to CD8+ T-lymphocyte ratio of both groups of cats inoculated with FIV. Infection with FeSFV had no effect on the CD4+ to CD8+ T-cell ratio. Mitogen stimulation assays and total WBC count were unaffected by FeSFV infection, although an increase in numbers of neutrophils from FeSFV-infected cats was consistent, especially when compared with the decrease observed after FIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0027597985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027597985&partnerID=8YFLogxK

M3 - Article

VL - 54

SP - 713

EP - 718

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 5

ER -