Evaluation of canine COL4A3 and COL4A4 as candidates for familial renal disease in the Norwegian elkhound

A. C. Wiersma, L. V. Millon, A. M. Van Dongen, B. A. Van Oost, Danika L Bannasch

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The collagen type IV α3 and α4 chains (COL4A3 and COL4A4) are part of the specialized glomerular basement membrane in the kidney. In human these genes are responsible for Alport syndrome (a type of hereditary nephritis). Histopathological similarities between kidneys of Norwegian elkhound dogs affected with familial renal disease and human Alport syndrome were the basis for a candidate gene approach in Norwegian elkhounds. Three microsatellites - tightly linked to canine COL4A3 and COL4A4 - were developed. The microsatellites were used to analyze linkage between COL4A3 and COL4A4 and familial renal disease in a Norwegian elkhound pedigree segregating this disease. Presence of one recombinant between familial renal disease and COL4A3/COL4A4 suggests that these genes are not likely candidates for familial renal disease in this breed.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalJournal of Heredity
Volume96
Issue number7
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

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