Evaluation of Bronchoscopy and Bronchoalveolar Lavage Findings in Cats With Aelurostrongylus abstrusus in Comparison to Cats With Feline Bronchial Disease

Paolo E. Crisi, Lynelle R. Johnson, Angela Di Cesare, Francesca De Santis, Morena Di Tommaso, Simone Morelli, Stefania Pantaleo, Alessia Luciani, Roland Schaper, Fabrizio Pampurini, Andrea Boari

Research output: Contribution to journalArticle

Abstract

The cat lungworm Aelurostrongylus abstrusus is a cause of lower respiratory tract disease worldwide. Bronchoscopy and bronchoalveolar lavage (BAL) are important tools for diagnosing respiratory diseases in cats. Therefore, the aim of the study was to investigate the usefulness of bronchoscopy and BAL in the diagnosis of A. abstrusus. Findings from bronchoscopic examination and BAL of 24 naturally infected cats were evaluated and compared with those of 12 cats with idiopathic Feline Bronchial Diseases (FBDs). Data were analyzed using Mann-Whitney or Fisher's exact tests. No significant bronchoscopic differences were detected between cats with aelurostrongylosis and FBDs in bronchial mucus, nodular lesions, and airway collapse. On the other hand, airway hyperemia, epithelial irregularities, and bronchial stenosis were observed more frequently in cats affected by FBDs than aelurostrongylosis, while bronchiectasis was found only in cats infected by A. abstrusus. Neutrophilic, eosinophilic, lymphocytic, and mixed inflammation were recorded in both groups. Bacteria or bacterial DNA was identified regardless of the presence or absence of A. abstrusus with no significant differences between groups. Larvae of A. abstrusus were cytologically detected in 5 of the 24 cats (20.8%) with aelurostrongylosis. These results indicate that, although some findings on bronchoscopic examination (i.e., bronchiectasis) can be described more frequently in cats infected by A. abstrusus, bronchial alterations and cytological findings in aelurostrongylosis are not specific unless larvae are observed and overlap with those of other feline airway diseases.

Original languageEnglish (US)
Article number337
JournalFrontiers in Veterinary Science
Volume6
DOIs
StatePublished - Oct 2 2019

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Bronchial Diseases
Aelurostrongylus
Cat Diseases
bronchoscopy
Bronchoscopy
Bronchoalveolar Lavage
Cats
cats
Bronchiectasis
Larva
Respiratory Tract Diseases
Bacterial DNA
respiratory tract diseases
Hyperemia
Mucus
cat diseases
lungworms
Pathologic Constriction
larvae
Inflammation

Keywords

  • aelurostrongylosis
  • bronchiectasis
  • bronchoalveolar lavage
  • bronchoschopy
  • feline bronchial disease

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of Bronchoscopy and Bronchoalveolar Lavage Findings in Cats With Aelurostrongylus abstrusus in Comparison to Cats With Feline Bronchial Disease. / Crisi, Paolo E.; Johnson, Lynelle R.; Di Cesare, Angela; De Santis, Francesca; Di Tommaso, Morena; Morelli, Simone; Pantaleo, Stefania; Luciani, Alessia; Schaper, Roland; Pampurini, Fabrizio; Boari, Andrea.

In: Frontiers in Veterinary Science, Vol. 6, 337, 02.10.2019.

Research output: Contribution to journalArticle

Crisi, Paolo E. ; Johnson, Lynelle R. ; Di Cesare, Angela ; De Santis, Francesca ; Di Tommaso, Morena ; Morelli, Simone ; Pantaleo, Stefania ; Luciani, Alessia ; Schaper, Roland ; Pampurini, Fabrizio ; Boari, Andrea. / Evaluation of Bronchoscopy and Bronchoalveolar Lavage Findings in Cats With Aelurostrongylus abstrusus in Comparison to Cats With Feline Bronchial Disease. In: Frontiers in Veterinary Science. 2019 ; Vol. 6.
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abstract = "The cat lungworm Aelurostrongylus abstrusus is a cause of lower respiratory tract disease worldwide. Bronchoscopy and bronchoalveolar lavage (BAL) are important tools for diagnosing respiratory diseases in cats. Therefore, the aim of the study was to investigate the usefulness of bronchoscopy and BAL in the diagnosis of A. abstrusus. Findings from bronchoscopic examination and BAL of 24 naturally infected cats were evaluated and compared with those of 12 cats with idiopathic Feline Bronchial Diseases (FBDs). Data were analyzed using Mann-Whitney or Fisher's exact tests. No significant bronchoscopic differences were detected between cats with aelurostrongylosis and FBDs in bronchial mucus, nodular lesions, and airway collapse. On the other hand, airway hyperemia, epithelial irregularities, and bronchial stenosis were observed more frequently in cats affected by FBDs than aelurostrongylosis, while bronchiectasis was found only in cats infected by A. abstrusus. Neutrophilic, eosinophilic, lymphocytic, and mixed inflammation were recorded in both groups. Bacteria or bacterial DNA was identified regardless of the presence or absence of A. abstrusus with no significant differences between groups. Larvae of A. abstrusus were cytologically detected in 5 of the 24 cats (20.8{\%}) with aelurostrongylosis. These results indicate that, although some findings on bronchoscopic examination (i.e., bronchiectasis) can be described more frequently in cats infected by A. abstrusus, bronchial alterations and cytological findings in aelurostrongylosis are not specific unless larvae are observed and overlap with those of other feline airway diseases.",
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AU - De Santis, Francesca

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AU - Morelli, Simone

AU - Pantaleo, Stefania

AU - Luciani, Alessia

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AU - Pampurini, Fabrizio

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