Evaluation of Bendectin embryotoxicity in nonhuman primates: II. Double‐blind study in term cynomolgus monkeys

Andrew G Hendrickx, M. Cukierski, S. Prahalada, G. Janos, S. Booher, T. Nyland

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The embryotoxic and teratogenic potential of Bendectin was assessed in this double‐blind study in the cynomolgus monkey (Macaca fascicularis). Bendectin was administered orally at doses approximately two, five, and 20 times the human dose equivalent from 22 ± 2 through 50 days of gestation. Fetuses were delivered by cesarean section near term and examined for malformations. There was no maternal toxicity as evidenced by maternal weights and physical signs. There was no correlation between dosage and the number of prenatal deaths. No significant abnormalities related to treatment were observed in postdelivery physical examinations, placental evaluations, external and internal gross examinations, or from radiographs of the neonates. Under the conditions of this study the treatment of pregnant cynomolgus monkeys with Bendectin produced no evidence of teratogenicity or embryo‐, or fetal‐, or maternal toxicity.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalTeratology
Volume32
Issue number2
DOIs
StatePublished - 1985

Fingerprint

Macaca fascicularis
Primates
Mothers
Toxicity
Cesarean Section
Physical Examination
Fetus
Embryonic Structures
Weights and Measures
Pregnancy
dicyclomine, doxylamine, pyridoxine drug combination

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

Cite this

Hendrickx, A. G., Cukierski, M., Prahalada, S., Janos, G., Booher, S., & Nyland, T. (1985). Evaluation of Bendectin embryotoxicity in nonhuman primates: II. Double‐blind study in term cynomolgus monkeys. Teratology, 32(2), 191-194. https://doi.org/10.1002/tera.1420320206

Evaluation of Bendectin embryotoxicity in nonhuman primates : II. Double‐blind study in term cynomolgus monkeys. / Hendrickx, Andrew G; Cukierski, M.; Prahalada, S.; Janos, G.; Booher, S.; Nyland, T.

In: Teratology, Vol. 32, No. 2, 1985, p. 191-194.

Research output: Contribution to journalArticle

Hendrickx, AG, Cukierski, M, Prahalada, S, Janos, G, Booher, S & Nyland, T 1985, 'Evaluation of Bendectin embryotoxicity in nonhuman primates: II. Double‐blind study in term cynomolgus monkeys', Teratology, vol. 32, no. 2, pp. 191-194. https://doi.org/10.1002/tera.1420320206
Hendrickx, Andrew G ; Cukierski, M. ; Prahalada, S. ; Janos, G. ; Booher, S. ; Nyland, T. / Evaluation of Bendectin embryotoxicity in nonhuman primates : II. Double‐blind study in term cynomolgus monkeys. In: Teratology. 1985 ; Vol. 32, No. 2. pp. 191-194.
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