Abstract
The embryotoxic and teratogenic potential of Bendectin was assessed in this double‐blind study in the cynomolgus monkey (Macaca fascicularis). Bendectin was administered orally at doses approximately two, five, and 20 times the human dose equivalent from 22 ± 2 through 50 days of gestation. Fetuses were delivered by cesarean section near term and examined for malformations. There was no maternal toxicity as evidenced by maternal weights and physical signs. There was no correlation between dosage and the number of prenatal deaths. No significant abnormalities related to treatment were observed in postdelivery physical examinations, placental evaluations, external and internal gross examinations, or from radiographs of the neonates. Under the conditions of this study the treatment of pregnant cynomolgus monkeys with Bendectin produced no evidence of teratogenicity or embryo‐, or fetal‐, or maternal toxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-194 |
| Number of pages | 4 |
| Journal | Teratology |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Embryology
- Toxicology
- Developmental Biology
- Health, Toxicology and Mutagenesis
Cite this
Evaluation of Bendectin embryotoxicity in nonhuman primates : II. Double‐blind study in term cynomolgus monkeys. / Hendrickx, Andrew G; Cukierski, M.; Prahalada, S.; Janos, G.; Booher, S.; Nyland, T.
In: Teratology, Vol. 32, No. 2, 1985, p. 191-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of Bendectin embryotoxicity in nonhuman primates
T2 - II. Double‐blind study in term cynomolgus monkeys
AU - Hendrickx, Andrew G
AU - Cukierski, M.
AU - Prahalada, S.
AU - Janos, G.
AU - Booher, S.
AU - Nyland, T.
PY - 1985
Y1 - 1985
N2 - The embryotoxic and teratogenic potential of Bendectin was assessed in this double‐blind study in the cynomolgus monkey (Macaca fascicularis). Bendectin was administered orally at doses approximately two, five, and 20 times the human dose equivalent from 22 ± 2 through 50 days of gestation. Fetuses were delivered by cesarean section near term and examined for malformations. There was no maternal toxicity as evidenced by maternal weights and physical signs. There was no correlation between dosage and the number of prenatal deaths. No significant abnormalities related to treatment were observed in postdelivery physical examinations, placental evaluations, external and internal gross examinations, or from radiographs of the neonates. Under the conditions of this study the treatment of pregnant cynomolgus monkeys with Bendectin produced no evidence of teratogenicity or embryo‐, or fetal‐, or maternal toxicity.
AB - The embryotoxic and teratogenic potential of Bendectin was assessed in this double‐blind study in the cynomolgus monkey (Macaca fascicularis). Bendectin was administered orally at doses approximately two, five, and 20 times the human dose equivalent from 22 ± 2 through 50 days of gestation. Fetuses were delivered by cesarean section near term and examined for malformations. There was no maternal toxicity as evidenced by maternal weights and physical signs. There was no correlation between dosage and the number of prenatal deaths. No significant abnormalities related to treatment were observed in postdelivery physical examinations, placental evaluations, external and internal gross examinations, or from radiographs of the neonates. Under the conditions of this study the treatment of pregnant cynomolgus monkeys with Bendectin produced no evidence of teratogenicity or embryo‐, or fetal‐, or maternal toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0021971885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021971885&partnerID=8YFLogxK
U2 - 10.1002/tera.1420320206
DO - 10.1002/tera.1420320206
M3 - Article
C2 - 4049276
AN - SCOPUS:0021971885
VL - 32
SP - 191
EP - 194
JO - Teratology
JF - Teratology
SN - 1542-0752
IS - 2
ER -