Evaluation of anti-inflammatory drugs based upon the inhibition of matrix-induced ornithine decarboxylase activity during connective tissue proliferation

N. C. Rath, A Hari Reddi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The ability of several steroidal and nonsteroidal antiinflammatory agents to locally inhibit bone matrix-induced ornithine decarboxylase activity was examined. All of the glucocorticoids tested had an inhibitory effect on ODC activity. The synthetic glucocorticoids dexamethasone, flucinolone acetonide, and betamethasone were most effective in inhibiting OCD activity whereas cortisol and corticosterone had minimal inhibitory effects. The effects of the glucocorticoids on ODC activity was correlated with their known antiinflammatory potency in other systems. Nonsteroidal drugs had a varying response in this system. Indomethacin and meclofenamic acid were potent inhibitors of ODC activity whereas acetyl salicylic acid, fenoprofane, and noproxane were ineffective in doses examined.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume162
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Evaluation of anti-inflammatory drugs based upon the inhibition of matrix-induced ornithine decarboxylase activity during connective tissue proliferation'. Together they form a unique fingerprint.

  • Cite this