Evaluation of a new automated quantitative d-dimer, advanced D-dimer, in patients suspected of venous thromboembolism

R. C. Gosselin, John T Owings, R. C. Jacoby, E. C. Larkin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The objective of our study was to evaluate the performance characteristics of a new automated d-dimer, the Advanced D-Dimer (Dade Behring Inc., Deerfield, IL) for use in the diagnosis of venous thromboembolism (VTE). To do this we compared the Advanced D-Dimer to existing d-dimer methods using established target cut-off values in patients suspected of VTE who were to undergo definitive radiographic studies for VTE. We studied hospitalized patients and outpatients who were suspected of having VTE and who had whole blood d-dimer performed. The patients who underwent a diagnostic study for VTE had their D-dimer results used to determine sensitivity, specificity and negative predictive values. There was relatively poor correlation between the Advanced D-Dimer and D-Dimer Gold (r= 0.63; t-test: P < 0.005) and Asserachrome D-Di (r= 0.58; t-test: P < 0.005). The Advanced D-Dimer target cutoff values for excluding VTE in hospitalized and outpatients were ≤ 1800 μg/L and ≤ 1500 μg/l respectively. There were 139 patients suspected with pulmonary embolism (PE) and 328 evaluated for deep vein thrombosis (DVT). There were 24 patients with PE, and 43 with DVT. The Advanced D-Dimer had comparable sensitivity, specificity and negative predictive values (96, 43, 98% for PE and 96, 48, 99% for DVT respectively) to other d-dimer methods used for that purpose. We conclude that the Advanced D-Dimer correlates relatively poorly with enzyme-linked immunosorbent assay methods. This poor correlation is likely due to incorrect reporting units and concentration. When these factors are corrected correlations improved. Compared to existing d-dimer methods used for VTE exclusion, the high sensitivity and negative predictive value would suggest that this method can be used as part of a diagnostic algorithm for the exclusion of PE and DVT.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalBlood Coagulation and Fibrinolysis
Volume13
Issue number4
DOIs
StatePublished - Jun 2002

Fingerprint

Venous Thromboembolism
Pulmonary Embolism
Venous Thrombosis
Outpatients
Sensitivity and Specificity
fibrin fragment D
Gold
Enzyme-Linked Immunosorbent Assay

Keywords

  • Advanced D-Dimer
  • D-dimer
  • Deep vein thrombosis
  • Pulmonary embolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Cite this

Evaluation of a new automated quantitative d-dimer, advanced D-dimer, in patients suspected of venous thromboembolism. / Gosselin, R. C.; Owings, John T; Jacoby, R. C.; Larkin, E. C.

In: Blood Coagulation and Fibrinolysis, Vol. 13, No. 4, 06.2002, p. 323-330.

Research output: Contribution to journalArticle

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