Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States

Megan H. Noe, Marilyn T. Wan, Arash Mostaghimi, Joel M. Gelfand, Ritesh Agnihothri, April W Armstrong, Tina Bhutani, Alina Bridges, Nicholas Brownstone, Melissa Butt, Kristina P.Callis Duffin, Christian Carr, Andrew Creadore, Katherine L. Deniro, Sheena Desai, Arturo R. Dominguez, Emily K. Duffy, Janet A. Fairley, Alisa Femia, Johann E. GudjonssonJessica A. Kaffenberger, Kimberly L. Katz, Joslyn S. Kirby, Stephanie T. Le, Edgar Martinez, Emanual Maverakis, Bridget Myers, Haley B. Naik, Caroline A. Nelson, Alex G. Ortega-Loayza, Molly E. Plovanich, Lauren K. Rangel, Vignesh Ravi, Vidhatha D. Reddy, Jamal Z. Saleh, Jeena K. Sandhu, Hadir Shakshouk, Bridget E. Shields, Zakariyah Sharif-Sidi, Jacob Smith, Amanda Steahr, Atrin Toussi, Karolyn A. Wanat, Bo Wang, Brian M. Wei, Annika Weinhammer, Scott D. Worswick, Alexander Yang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Importance: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. Objective: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. Design, Setting, and Participants: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. Main Outcomes and Measures: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. Results: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. Conclusions and Relevance: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalJAMA Dermatology
Volume158
Issue number1
DOIs
StatePublished - Jan 2022

ASJC Scopus subject areas

  • Dermatology

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