Evaluating the temporal context of episodic memory: The role of CA3 and CA1

Michael R. Hunsaker, Bart Lee, Raymond P. Kesner

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

It has been suggested that the hippocampus mediates episodic memory processing involving snapshot memory and temporal sequence learning. To test this theory, rats learned trial-unique sequences of spatial locations along a runway box and were tested on recall by removing one of the locations in the sequence and making the rat choose the correct location to be rewarded. Once animals were able to reliably perform this episodic memory task, they received lesions to either CA3 or CA1. Animals with lesions to either CA3 or CA1 had difficulty with episodic memory processing, although CA1 lesioned animals had a much greater deficit. However, when animals were trained on a non-episodic version of the same task, hippocampal lesions had no effect. These results suggest that CA3 and CA1 both contribute to episodic memory processing since lesions to CA3 or CA1 result in an inability to process spatial information episodically, whereas they have no effect on non-episodic information processing.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalBehavioural Brain Research
Volume188
Issue number2
DOIs
StatePublished - Apr 9 2008
Externally publishedYes

Keywords

  • CA1
  • CA3
  • Episodic memory
  • Spatial information processing
  • Temporal context

ASJC Scopus subject areas

  • Behavioral Neuroscience

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