European population substructure: clustering of northern and southern populations.

Michael F Seldin, Russell Shigeta, Pablo Villoslada, Carlo Selmi, Jaakko Tuomilehto, Gabriel Silva, John W. Belmont, Lars Klareskog, Peter K. Gregersen

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between "northern" and "southern" European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the "southern" population; and most northern, western, eastern, and central Europeans have >90% in the "northern" population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the "southern" population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.

Original languageEnglish (US)
JournalPLoS Genetics
Volume2
Issue number9
DOIs
StatePublished - Sep 15 2006

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

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    Seldin, M. F., Shigeta, R., Villoslada, P., Selmi, C., Tuomilehto, J., Silva, G., Belmont, J. W., Klareskog, L., & Gregersen, P. K. (2006). European population substructure: clustering of northern and southern populations. PLoS Genetics, 2(9). https://doi.org/10.1371/journal.pgen.0020143