TY - JOUR
T1 - European population substructure
T2 - clustering of northern and southern populations.
AU - Seldin, Michael F
AU - Shigeta, Russell
AU - Villoslada, Pablo
AU - Selmi, Carlo
AU - Tuomilehto, Jaakko
AU - Silva, Gabriel
AU - Belmont, John W.
AU - Klareskog, Lars
AU - Gregersen, Peter K.
PY - 2006/9/15
Y1 - 2006/9/15
N2 - Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between "northern" and "southern" European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the "southern" population; and most northern, western, eastern, and central Europeans have >90% in the "northern" population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the "southern" population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.
AB - Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between "northern" and "southern" European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the "southern" population; and most northern, western, eastern, and central Europeans have >90% in the "northern" population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the "southern" population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.
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U2 - 10.1371/journal.pgen.0020143
DO - 10.1371/journal.pgen.0020143
M3 - Article
C2 - 17044734
AN - SCOPUS:33749372240
VL - 2
JO - PLoS Genetics
JF - PLoS Genetics
SN - 1553-7390
IS - 9
ER -