European population genetic substructure: Further definition of ancestry informative markers for distinguishing among diverse European ethnic groups

Chao Tian, Roman Kosoy, Rami Nassir, Annette Lee, Pablo Villoslada, Lars Klareskog, Lennart Hammarström, Henri Jean Garchon, Ann E. Pulver, Michael Ransom, Peter K. Gregersen, Michael F Seldin

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4,000 subjects genotyped for 300,000 single-nucleotide polymorphisms (SNPs), we provide further insight into relationships among European population groups and identify sets of SNP ancestry informative markers (AIMs) for application in genetic studies. In general, the graphical description of these principal components analyses (PCA) of diverse European subjects showed a strong correspondence to the geographical relationships of specific countries or regions of origin. Clearer separation of different ethnic and regional populations was observed when northern and southern European groups were considered separately and the PCA results were influenced by the inclusion or exclusion of different self-identified population groups including Ashkenazi Jewish, Sardinian, and Orcadian ethnic groups. SNP AIM sets were identified that could distinguish the regional and ethnic population groups. Moreover, the studies demonstrated that most allele frequency differences between different European groups could be controlled effectively in analyses using these AIM sets. The European substructure AIMs should be widely applicable to ongoing studies to confirm and delineate specific disease susceptibility candidate regions without the necessity of performing additional genome-wide SNP studies in additional subject sets.

Original languageEnglish (US)
Pages (from-to)371-383
Number of pages13
JournalMolecular Medicine
Volume15
Issue number11-12
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

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    Tian, C., Kosoy, R., Nassir, R., Lee, A., Villoslada, P., Klareskog, L., Hammarström, L., Garchon, H. J., Pulver, A. E., Ransom, M., Gregersen, P. K., & Seldin, M. F. (2009). European population genetic substructure: Further definition of ancestry informative markers for distinguishing among diverse European ethnic groups. Molecular Medicine, 15(11-12), 371-383. https://doi.org/10.2119/molmed.2009.00094