Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women

K. K. Ryckman, E. Rillamas-Sun, C. N. Spracklen, R. B. Wallace, Lorena Garcia, F. A. Tylavsky, B. V. Howard, S. Liu, Y. Song, E. S. LeBlanc, M. V. White, N. I. Parikh, J. G. Robinson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aim: The objective of this study is to examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women. Methods: Baseline data from the Women's Health Initiative Observational Study [. n=. 75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes mellitus. Models were adjusted for age, ethnicity, body mass index and other pertinent risk factors. Sub-analyses were performed stratifying by ethnicity. Results: There was a strong inverse association between birth weight and type 2 diabetes mellitus with a birth weight of <6 pounds (lbs) (OR: 1.16, 95% CI: 1.01, 1.33) significantly associated with an increased risk of type 2 diabetes mellitus and a birth weight of ≥10 lbs (OR: 0.72, 95% CI: 0.57, 0.92) associated with a decreased risk of type 2 diabetes mellitus compared to women who reported their birth weight between 7 and 8 lbs 15 ounces (oz). Stratifying by ethnicity, the inverse association between birth weight and type 2 diabetes mellitus was only apparent in White women, but not Black, Hispanic or Asian women. Conclusion: Lower birth weight was associated with increased T2D risk in American White and Black post-menopausal women.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalDiabetes and Metabolism
Volume40
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Birth weight
  • Diabetes
  • Fetal programming

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women'. Together they form a unique fingerprint.

  • Cite this

    Ryckman, K. K., Rillamas-Sun, E., Spracklen, C. N., Wallace, R. B., Garcia, L., Tylavsky, F. A., Howard, B. V., Liu, S., Song, Y., LeBlanc, E. S., White, M. V., Parikh, N. I., & Robinson, J. G. (2014). Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women. Diabetes and Metabolism, 40(5), 379-385. https://doi.org/10.1016/j.diabet.2014.03.003