Ethics in the Use of Animal Models of Seizures and Epilepsy

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter considers ethical issues of major importance in the use of animal models in seizure and epilepsy research. The chapter discusses the nature, subject matter, and importance of biomedical animal research ethics. The chapter presents principles of biomedical animal research ethics that play a central role in individual research projects, and animal experimentation generally. Three issues of special significance in animal seizure and epilepsy research are emphasized: (1) how investigators should define "basic" animal research, and how they should approach one kind of ethical objection to such research; (2) the ethical requirement that pain, distress, and other severe harms that might be experienced by animals must be minimized; and (3) the ethical requirement that any unrelieved pain, distress, or other severe harms experienced by animals in an experiment must be justified by the value of the experiment.

Original languageEnglish (US)
Title of host publicationModels of Seizures and Epilepsy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages22
ISBN (Print)9780128040669
StatePublished - Jan 1 2017


  • Basic research
  • Biomedical animal research ethics
  • Distress
  • Ethics
  • Harm
  • Harm-benefit analysis
  • Pain
  • Reduction
  • Refinement
  • Replacement

ASJC Scopus subject areas

  • Neuroscience(all)


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