Abstract
This chapter presents an overview of the ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for the application of these principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for the resolution of these issues. Recommendations are offered for the participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.
Original language | English (US) |
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Title of host publication | Animal Models for the Study of Human Disease |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 1-44 |
Number of pages | 44 |
ISBN (Electronic) | 9780124158948 |
ISBN (Print) | 9780128094686 |
DOIs | |
State | Published - Jun 28 2017 |
Keywords
- Basic research
- Biomedical animal research ethics
- Ethics
- Harm
- Harm-benefit analysis
- Reduction
- Refinement
- Replacement
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)