Ethics in Biomedical Animal Research: The Key Role of the Investigator

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.

Original languageEnglish (US)
Title of host publicationAnimal Models for the Study of Human Disease
PublisherElsevier Inc.
Number of pages34
ISBN (Print)9780124158948
StatePublished - Jan 1 2013
Externally publishedYes


  • Alternatives
  • Animal research ethics
  • Distress
  • Environmental enrichment
  • Ethics
  • Harms
  • Pain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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