Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis

Kentaro Kikuchi, Atsushi Tanaka, Hiroshi Miyakawa, Yumi Kawashima, Naomi Kawaguchi, Masano Matsushita, M. Eric Gershwin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Early T-lymphocyte activation 1 (Eta-1)/osteopontin is a soluble ligand with pleomorphic immunologic activities including activation of macrophage chemotaxis, promotion of TH1 responses, and activation of B1 B-cells. A recent study suggested that a single-nucleotide polymorphism (SNP) at position nt 9250 (C to T) in exon 7 was highly associated with systemic lupus erythematosus (SLE). Eta-1/osteopontin was reported to be highly expressed in the MRL/lpr mouse, which is recognized as one of the spontaneous autoimmune models of SLE. In the present study, we first investigated the association with this SNP and susceptibility to primary biliary cirrhosis (PBC). The allele frequencies of C/C, C/T, and T/T at position nt 9250 on the Eta-1/osteopontin gene in 50 PBC patients were 20, 32, and 48%, respectively, compared with 9, 47, and 44% in 34 healthy controls (P < 0.16-0.72). The gene frequencies of C and T at this position in such PBC patients were 0.36 and 0.64, whereas those in the healthy controls were 0.32 and 0.68 (P < 0.91), respectively. Moreover, clinical findings and pathologic stages were not correlated with the variation of SNP. Those findings suggest no associations with Eta-1/osteopontin genetic polymorphism and susceptibility to PBC.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalHepatology Research
Volume26
Issue number2
DOIs
StatePublished - Jun 1 2003

Fingerprint

Osteopontin
Biliary Liver Cirrhosis
Genetic Polymorphisms
Lymphocyte Activation
Single Nucleotide Polymorphism
T-Lymphocytes
Gene Frequency
Systemic Lupus Erythematosus
Inbred MRL lpr Mouse
Macrophage Activation
Chemotaxis
Genetic Predisposition to Disease
Exons
B-Lymphocytes
Ligands
Genes

Keywords

  • Eta-1/osteopontin
  • Restriction fragment length polymorphism
  • Single-nucleotide polymorphism

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kikuchi, K., Tanaka, A., Miyakawa, H., Kawashima, Y., Kawaguchi, N., Matsushita, M., & Gershwin, M. E. (2003). Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis. Hepatology Research, 26(2), 87-90. https://doi.org/10.1016/S1386-6346(03)00012-3

Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis. / Kikuchi, Kentaro; Tanaka, Atsushi; Miyakawa, Hiroshi; Kawashima, Yumi; Kawaguchi, Naomi; Matsushita, Masano; Gershwin, M. Eric.

In: Hepatology Research, Vol. 26, No. 2, 01.06.2003, p. 87-90.

Research output: Contribution to journalArticle

Kikuchi, K, Tanaka, A, Miyakawa, H, Kawashima, Y, Kawaguchi, N, Matsushita, M & Gershwin, ME 2003, 'Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis', Hepatology Research, vol. 26, no. 2, pp. 87-90. https://doi.org/10.1016/S1386-6346(03)00012-3
Kikuchi K, Tanaka A, Miyakawa H, Kawashima Y, Kawaguchi N, Matsushita M et al. Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis. Hepatology Research. 2003 Jun 1;26(2):87-90. https://doi.org/10.1016/S1386-6346(03)00012-3
Kikuchi, Kentaro ; Tanaka, Atsushi ; Miyakawa, Hiroshi ; Kawashima, Yumi ; Kawaguchi, Naomi ; Matsushita, Masano ; Gershwin, M. Eric. / Eta-1/osteopontin genetic polymorphism and primary biliary cirrhosis. In: Hepatology Research. 2003 ; Vol. 26, No. 2. pp. 87-90.
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