Estrogen, NFκB, and the heat shock response

James P. Stice, Anne A Knowlton

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Estrogen has pleiotropic actions, among which are its anti-apoptotic, anti-inflammatory, and vasodilatory effects. Recently, an interaction between 17β-estradiol (E2) and the transcription factor nuclear factor κB (NFκB) has been identified. NFκB has a central role in the control of genes involved in inflammation, proliferation, and apoptosis. Prolonged activation of NFκB is associated with numerous inflammatory pathological conditions. An important facet of E2 is its ability to modulate activity of NFκB via both genomic and nongenomic actions. E2 can activate NFκB rapidly via nongenomic pathways, increase cellular resistance to injury, and induce expression of the protective class of proteins, heat shock proteins (HSPs). HSPs can bind to many of the pro-apoptotic and pro-inflammatory targets of NF?B and, thus, indirectly inhibit many of its deleterious effects. In addition, HSPs can block NFκB activation and binding directly. Similarly, genomic E2 signaling can inhibit NFκB, but does so through alternative mechanisms. This review focuses on the molecular mechanisms of cross-talk between E2, NFκB, and HSPs, and the biological relevance of this cross-talk.

Original languageEnglish (US)
Pages (from-to)517-527
Number of pages11
JournalMolecular Medicine
Volume14
Issue number7-8
DOIs
StatePublished - Jul 2008

Fingerprint

Heat-Shock Response
Heat-Shock Proteins
Estrogens
Estradiol
Anti-Inflammatory Agents
Transcription Factors
Apoptosis
Inflammation
Wounds and Injuries
Genes
Proteins

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Estrogen, NFκB, and the heat shock response. / Stice, James P.; Knowlton, Anne A.

In: Molecular Medicine, Vol. 14, No. 7-8, 07.2008, p. 517-527.

Research output: Contribution to journalArticle

Stice, James P. ; Knowlton, Anne A. / Estrogen, NFκB, and the heat shock response. In: Molecular Medicine. 2008 ; Vol. 14, No. 7-8. pp. 517-527.
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