Estrogen induction of a small, putative K+ channel mRNA in rat uterus

M. Pragnell, K. J. Snay, James Trimmer, N. J. MacLusky, F. Naftolin, L. K. Kaczmarek, M. B. Boyle

Research output: Contribution to journalArticle

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Abstract

Estrogen causes dramatic long-term changes in the activity of the uterus. Here we report the molecular cloning of a small (700 base) uterine mRNA species capable of inducing a slow K+ current in Xenopus oocytes. The 130 amino acid protein encoded by this mRNA species has a predicted structure that does not resemble that of previously described voltage-dependent channels from mammalian sources. It is, however, similar to structural motifs found in certain prokaryotic ion channels. The induction of this mRNA by estrogen is rapid; this uterine mRNA species is not detectable in uteri from estrogen-deprived rats, but is substantially induced after 3 hr of estrogen treatment. These results support a critical role for regulation of ion channel expression by estrogen in the uterus.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalNeuron
Volume4
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Uterus
Estrogens
Messenger RNA
Ion Channels
Potassium Chloride
Molecular Cloning
Xenopus
Oocytes
Amino Acids
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pragnell, M., Snay, K. J., Trimmer, J., MacLusky, N. J., Naftolin, F., Kaczmarek, L. K., & Boyle, M. B. (1990). Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron, 4(5), 807-812. https://doi.org/10.1016/0896-6273(90)90207-V

Estrogen induction of a small, putative K+ channel mRNA in rat uterus. / Pragnell, M.; Snay, K. J.; Trimmer, James; MacLusky, N. J.; Naftolin, F.; Kaczmarek, L. K.; Boyle, M. B.

In: Neuron, Vol. 4, No. 5, 1990, p. 807-812.

Research output: Contribution to journalArticle

Pragnell, M, Snay, KJ, Trimmer, J, MacLusky, NJ, Naftolin, F, Kaczmarek, LK & Boyle, MB 1990, 'Estrogen induction of a small, putative K+ channel mRNA in rat uterus', Neuron, vol. 4, no. 5, pp. 807-812. https://doi.org/10.1016/0896-6273(90)90207-V
Pragnell M, Snay KJ, Trimmer J, MacLusky NJ, Naftolin F, Kaczmarek LK et al. Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron. 1990;4(5):807-812. https://doi.org/10.1016/0896-6273(90)90207-V
Pragnell, M. ; Snay, K. J. ; Trimmer, James ; MacLusky, N. J. ; Naftolin, F. ; Kaczmarek, L. K. ; Boyle, M. B. / Estrogen induction of a small, putative K+ channel mRNA in rat uterus. In: Neuron. 1990 ; Vol. 4, No. 5. pp. 807-812.
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