Estrogen induction of a small, putative K+ channel mRNA in rat uterus

M. Pragnell, K. J. Snay, James Trimmer, N. J. MacLusky, F. Naftolin, L. K. Kaczmarek, M. B. Boyle

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Abstract

Estrogen causes dramatic long-term changes in the activity of the uterus. Here we report the molecular cloning of a small (700 base) uterine mRNA species capable of inducing a slow K+ current in Xenopus oocytes. The 130 amino acid protein encoded by this mRNA species has a predicted structure that does not resemble that of previously described voltage-dependent channels from mammalian sources. It is, however, similar to structural motifs found in certain prokaryotic ion channels. The induction of this mRNA by estrogen is rapid; this uterine mRNA species is not detectable in uteri from estrogen-deprived rats, but is substantially induced after 3 hr of estrogen treatment. These results support a critical role for regulation of ion channel expression by estrogen in the uterus.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalNeuron
Volume4
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pragnell, M., Snay, K. J., Trimmer, J., MacLusky, N. J., Naftolin, F., Kaczmarek, L. K., & Boyle, M. B. (1990). Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron, 4(5), 807-812. https://doi.org/10.1016/0896-6273(90)90207-V