Estrogen induction of a small, putative K+ channel mRNA in rat uterus

M. Pragnell, K. J. Snay, James Trimmer, N. J. MacLusky, F. Naftolin, L. K. Kaczmarek, M. B. Boyle

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Estrogen causes dramatic long-term changes in the activity of the uterus. Here we report the molecular cloning of a small (700 base) uterine mRNA species capable of inducing a slow K+ current in Xenopus oocytes. The 130 amino acid protein encoded by this mRNA species has a predicted structure that does not resemble that of previously described voltage-dependent channels from mammalian sources. It is, however, similar to structural motifs found in certain prokaryotic ion channels. The induction of this mRNA by estrogen is rapid; this uterine mRNA species is not detectable in uteri from estrogen-deprived rats, but is substantially induced after 3 hr of estrogen treatment. These results support a critical role for regulation of ion channel expression by estrogen in the uterus.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
Issue number5
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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