Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

Shawn G. Hayes, Nicolas B. Moya Del Pino, Marc P Kaufman

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Static exercise is well known to increase heart rate, arterial blood pressure, and ventilation. These increases appear to be less in women than in men, a difference that has been attributed to an effect of estrogen on neuronal function. In decerebrate male cats, we examined the effect of estrogen (17β-estradiol; 0.001, 0.01, 0.1, and 1.0 μg/kg iv) on the cardiovascular and ventilatory responses to central command and the exercise pressor reflex, the two neural mechanisms responsible for evoking the autonomic and ventilatory responses to exercise. We found that 17β-estradiol, in each of the three doses tested, attenuated the pressor, cardioaccelerator, and phrenic nerve responses to electrical stimulation of the mesencephalic locomotor region (i.e., central command). In contrast, none of the doses of 17β-estradiol had any effect on the pressor, cardioaccelerator, and ventilatory responses to static contraction or stretch of the triceps surae muscles. We conclude that, in decerebrate male cats, estrogen injected intravenously attenuates cardiovascular and ventilatory responses to central command but has no effect on responses to the exercise pressor reflex.

    Original languageEnglish (US)
    Pages (from-to)1635-1641
    Number of pages7
    JournalJournal of Applied Physiology
    Volume92
    Issue number4
    StatePublished - 2002

    Fingerprint

    Estrogens
    Cats
    Exercise
    Estradiol
    Reflex
    Phrenic Nerve
    Electric Stimulation
    Ventilation
    Arterial Pressure
    Heart Rate
    Muscles

    Keywords

    • Arterial blood pressure
    • Exercise pressor reflex
    • Heart rate
    • Muscle afferents
    • Tendon stretch

    ASJC Scopus subject areas

    • Endocrinology
    • Physiology
    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

    Cite this

    Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats. / Hayes, Shawn G.; Moya Del Pino, Nicolas B.; Kaufman, Marc P.

    In: Journal of Applied Physiology, Vol. 92, No. 4, 2002, p. 1635-1641.

    Research output: Contribution to journalArticle

    Hayes, Shawn G. ; Moya Del Pino, Nicolas B. ; Kaufman, Marc P. / Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats. In: Journal of Applied Physiology. 2002 ; Vol. 92, No. 4. pp. 1635-1641.
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