Abstract
Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 494-497 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 77 |
| Issue number | 2 |
| State | Published - Aug 1993 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia. / Caticha, Omar; Odell, William D.; Wilson, Dana E.; Dowdell, Lynn A.; Noth, Robert H.; Swislocki, Arthur L; Lamothe, Jacques J.; Barrow, Roger.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 77, No. 2, 08.1993, p. 494-497.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia
AU - Caticha, Omar
AU - Odell, William D.
AU - Wilson, Dana E.
AU - Dowdell, Lynn A.
AU - Noth, Robert H.
AU - Swislocki, Arthur L
AU - Lamothe, Jacques J.
AU - Barrow, Roger
PY - 1993/8
Y1 - 1993/8
N2 - Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome.
AB - Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0027323886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027323886&partnerID=8YFLogxK
M3 - Article
C2 - 8345057
AN - SCOPUS:0027323886
VL - 77
SP - 494
EP - 497
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -