Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia

Omar Caticha, William D. Odell, Dana E. Wilson, Lynn A. Dowdell, Robert H. Noth, Arthur L Swislocki, Jacques J. Lamothe, Roger Barrow

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number2
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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    Caticha, O., Odell, W. D., Wilson, D. E., Dowdell, L. A., Noth, R. H., Swislocki, A. L., Lamothe, J. J., & Barrow, R. (1993). Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia. Journal of Clinical Endocrinology and Metabolism, 77(2), 494-497.