Estradiol, SHBG and leptin interplay with food craving and intake across the menstrual cycle

Sridevi Krishnan, Rebecca R. Tryon, William F. Horn, Lucas Welch, Nancy L. Keim

Research output: Contribution to journalArticle

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Abstract

Objective To understand the association between ovarian hormones, non-acute satiety hormones and craving calorie dense foods in the luteal phase. Methods 17 premenopausal women, mean age 23.2 y, mean BMI 22.4 kg/m2 with regular menstrual cycles were studied during late follicular (FP) and luteal phases (LP). Estradiol, progesterone, DHEAS, SHBG, insulin and leptin, were measured in fasting samples. The validated Food Craving Inventory was used to record the types of foods volunteers habitually ate – rich in fat, carbohydrate or sweet taste, as well as craved during the LP of their menstrual cycle. Results Estradiol was inversely associated with leptin in FP (r = − 0.62, p = 0.01). Leptin was inversely associated with habitual intake of sweet foods, in both phases (FP: r = − 0.64, p = 0.01; LP: r = − 0.63, p = 0.01). SHBG in LP was positively associated with craving sweet and carbohydrate rich foods. Hierarchical cluster analysis revealed two groups of women, one with high estradiol, high estradiol/leptin ratio, high sweet and carbohydrate cravings (p < 0.05); the other group had lower estradiol, lower estradiol/leptin ratio, and reported less craving. Conclusions The estradiol-leptin axis may be a determinant of luteal phase craving and habitual food intake in menstruating women. Clinical Trial Registration Number: NCT01407692

LanguageEnglish (US)
Pages304-312
Number of pages9
JournalPhysiology and Behavior
Volume165
DOIs
StatePublished - Oct 15 2016

Fingerprint

Menstrual Cycle
Leptin
Luteal Phase
Estradiol
Eating
Food
Carbohydrates
Hormones
Follicular Phase
Craving
Intake
Progesterone
Cluster Analysis
Volunteers
Fasting
Fats
Clinical Trials
Insulin
Equipment and Supplies

Keywords

  • Craving
  • Estradiol
  • Food intake
  • Leptin
  • Sex hormones

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Philosophy
  • Behavioral Neuroscience

Cite this

Estradiol, SHBG and leptin interplay with food craving and intake across the menstrual cycle. / Krishnan, Sridevi; Tryon, Rebecca R.; Horn, William F.; Welch, Lucas; Keim, Nancy L.

In: Physiology and Behavior, Vol. 165, 15.10.2016, p. 304-312.

Research output: Contribution to journalArticle

Krishnan, Sridevi ; Tryon, Rebecca R. ; Horn, William F. ; Welch, Lucas ; Keim, Nancy L. / Estradiol, SHBG and leptin interplay with food craving and intake across the menstrual cycle. In: Physiology and Behavior. 2016 ; Vol. 165. pp. 304-312.
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AB - Objective To understand the association between ovarian hormones, non-acute satiety hormones and craving calorie dense foods in the luteal phase. Methods 17 premenopausal women, mean age 23.2 y, mean BMI 22.4 kg/m2 with regular menstrual cycles were studied during late follicular (FP) and luteal phases (LP). Estradiol, progesterone, DHEAS, SHBG, insulin and leptin, were measured in fasting samples. The validated Food Craving Inventory was used to record the types of foods volunteers habitually ate – rich in fat, carbohydrate or sweet taste, as well as craved during the LP of their menstrual cycle. Results Estradiol was inversely associated with leptin in FP (r = − 0.62, p = 0.01). Leptin was inversely associated with habitual intake of sweet foods, in both phases (FP: r = − 0.64, p = 0.01; LP: r = − 0.63, p = 0.01). SHBG in LP was positively associated with craving sweet and carbohydrate rich foods. Hierarchical cluster analysis revealed two groups of women, one with high estradiol, high estradiol/leptin ratio, high sweet and carbohydrate cravings (p < 0.05); the other group had lower estradiol, lower estradiol/leptin ratio, and reported less craving. Conclusions The estradiol-leptin axis may be a determinant of luteal phase craving and habitual food intake in menstruating women. Clinical Trial Registration Number: NCT01407692

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