Estimation of vascular density and blood velocity in tumors

Amy Sadlowski-Broumas, Rachel Pollard, Alyssa Taylor, Stephen Griffey, Erik Wisner, Katherine W Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We have completed a series of validation studies to demonstrate that ultrasound with a contrast agent and perfusion estimator is a reliable, accurate, and non-invasive method of measuring blood flow. A subharmonic phase-inversion detection scheme (Chomas et al.) was implemented on a Siemens Elegra scanner. A fluorescent microsphere study was completed in which high correlation was found between the spatial integral of flow obtained from ultrasound derived parameters and the microsphere measurement of ml of flow/minute/gram of tissue. We seek to further validate our results by showing a high degree of spatial correlation between US images and those acquired using histological analysis. In addition, contrast-enhanced ultrasound imaging studies were completed using a rat mammary adenocarcinoma model to evaluate the performance of an anti-angiogenic drug. Mean replenishment times and integrated enhancement values were calculated and differences between treated and control tumors were evaluated. The spatial extent of flow and the spatial integral of flow were calculated from the histograms of integrated enhancement and provide a method of comparison between tumors treated with the anti-angiogenic drug and control tumors. These parameters demonstrate a significant difference between the treated and control groups (P<0.05). A significant difference was not present in these parameters between groups prior to the onset of treatment (P>0.1).

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsD.E. Yuhas, S.C. Schneider
Pages645-648
Number of pages4
Volume1
StatePublished - 2003
Event2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States
Duration: Oct 5 2003Oct 8 2003

Other

Other2003 IEEE Ultrasonics Symposium - Proceedings
CountryUnited States
CityHonolulu, HI
Period10/5/0310/8/03

ASJC Scopus subject areas

  • Engineering(all)

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    Sadlowski-Broumas, A., Pollard, R., Taylor, A., Griffey, S., Wisner, E., & Ferrara, K. W. (2003). Estimation of vascular density and blood velocity in tumors. In D. E. Yuhas, & S. C. Schneider (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 1, pp. 645-648)