Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy

George Kaysen, Fansan Zhu, Shubho Sarkar, Steven B. Heymsfield, Jack Wong, Charoen Kaitwatcharachai, Martin K. Kuhlmann, Nathan W. Levin

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive. Objective: We evaluated the use of multifrequency bioimpedance spectroscopy (BIS) measurements of intracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients. Design: TBMM was measured by MRI in 20 male and 18 female hemodialysis patients with a median (range) age of 54 y (33-73 y), weight of 78.9 kg (43.2-120 kg), and body mass index (BMI; in kg/m2) of 27.3 (19.4-46.6). We measured total body water (TBW) by using D2O dilution, extracellular volume (ECV) as bromide space, and ICV as TBW minus bromide space. Total body potassium (TBK) measured as 40K was used as an independent model of TBMM. BIS was used to measure whole-body TBW (ankle to wrist) and TBW in the arms and legs. BIS-estimated ICV was used to construct models to calculate limb muscle mass and TBMM. The latter was compared with models derived from isotopic methods. Results: BIS yielded a model for TBMM [TBMM = 9.52 + 0.331 × ICV + 2.77 (male) + 0.180 × weight (kg) - 0.133 × age] (R2 = 0.937, P < 0.0001) as precise as TBK-measured TBMM [TBMM = 1.29 + 0.00453 × TBK (mEq) + 1.46 (male) + 0.144 × weight (kg) - 0.0565 × age] (R2 = 0.930, P < 0.0001) or isotopic methods. BIS models were also developed for measuring leg and arm muscle mass. Conclusion: BIS provides an estimate of TBMM that correlates well with isotopic methods in approximating values obtained by MRI and can be used to estimate limb muscle mass.

Original languageEnglish (US)
Pages (from-to)988-995
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number5
StatePublished - 2005

Fingerprint

hemodialysis
bioelectrical impedance
limbs (animal)
Renal Dialysis
spectroscopy
Spectrum Analysis
Skeletal Muscle
Extremities
skeletal muscle
Muscles
muscles
Body Water
body water
magnetic resonance imaging
Magnetic Resonance Imaging
Bromides
Weights and Measures
Leg
Arm
bromides

Keywords

  • Bioimpedance spectroscopy
  • Body cell mass
  • Body composition
  • Extracellular fluid
  • Hemodialysis patients
  • Nutrition
  • Total body water

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Kaysen, G., Zhu, F., Sarkar, S., Heymsfield, S. B., Wong, J., Kaitwatcharachai, C., ... Levin, N. W. (2005). Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy. American Journal of Clinical Nutrition, 82(5), 988-995.

Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy. / Kaysen, George; Zhu, Fansan; Sarkar, Shubho; Heymsfield, Steven B.; Wong, Jack; Kaitwatcharachai, Charoen; Kuhlmann, Martin K.; Levin, Nathan W.

In: American Journal of Clinical Nutrition, Vol. 82, No. 5, 2005, p. 988-995.

Research output: Contribution to journalArticle

Kaysen, G, Zhu, F, Sarkar, S, Heymsfield, SB, Wong, J, Kaitwatcharachai, C, Kuhlmann, MK & Levin, NW 2005, 'Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy', American Journal of Clinical Nutrition, vol. 82, no. 5, pp. 988-995.
Kaysen, George ; Zhu, Fansan ; Sarkar, Shubho ; Heymsfield, Steven B. ; Wong, Jack ; Kaitwatcharachai, Charoen ; Kuhlmann, Martin K. ; Levin, Nathan W. / Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 5. pp. 988-995.
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abstract = "Background: Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive. Objective: We evaluated the use of multifrequency bioimpedance spectroscopy (BIS) measurements of intracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients. Design: TBMM was measured by MRI in 20 male and 18 female hemodialysis patients with a median (range) age of 54 y (33-73 y), weight of 78.9 kg (43.2-120 kg), and body mass index (BMI; in kg/m2) of 27.3 (19.4-46.6). We measured total body water (TBW) by using D2O dilution, extracellular volume (ECV) as bromide space, and ICV as TBW minus bromide space. Total body potassium (TBK) measured as 40K was used as an independent model of TBMM. BIS was used to measure whole-body TBW (ankle to wrist) and TBW in the arms and legs. BIS-estimated ICV was used to construct models to calculate limb muscle mass and TBMM. The latter was compared with models derived from isotopic methods. Results: BIS yielded a model for TBMM [TBMM = 9.52 + 0.331 × ICV + 2.77 (male) + 0.180 × weight (kg) - 0.133 × age] (R2 = 0.937, P < 0.0001) as precise as TBK-measured TBMM [TBMM = 1.29 + 0.00453 × TBK (mEq) + 1.46 (male) + 0.144 × weight (kg) - 0.0565 × age] (R2 = 0.930, P < 0.0001) or isotopic methods. BIS models were also developed for measuring leg and arm muscle mass. Conclusion: BIS provides an estimate of TBMM that correlates well with isotopic methods in approximating values obtained by MRI and can be used to estimate limb muscle mass.",
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T1 - Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy

AU - Kaysen, George

AU - Zhu, Fansan

AU - Sarkar, Shubho

AU - Heymsfield, Steven B.

AU - Wong, Jack

AU - Kaitwatcharachai, Charoen

AU - Kuhlmann, Martin K.

AU - Levin, Nathan W.

PY - 2005

Y1 - 2005

N2 - Background: Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive. Objective: We evaluated the use of multifrequency bioimpedance spectroscopy (BIS) measurements of intracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients. Design: TBMM was measured by MRI in 20 male and 18 female hemodialysis patients with a median (range) age of 54 y (33-73 y), weight of 78.9 kg (43.2-120 kg), and body mass index (BMI; in kg/m2) of 27.3 (19.4-46.6). We measured total body water (TBW) by using D2O dilution, extracellular volume (ECV) as bromide space, and ICV as TBW minus bromide space. Total body potassium (TBK) measured as 40K was used as an independent model of TBMM. BIS was used to measure whole-body TBW (ankle to wrist) and TBW in the arms and legs. BIS-estimated ICV was used to construct models to calculate limb muscle mass and TBMM. The latter was compared with models derived from isotopic methods. Results: BIS yielded a model for TBMM [TBMM = 9.52 + 0.331 × ICV + 2.77 (male) + 0.180 × weight (kg) - 0.133 × age] (R2 = 0.937, P < 0.0001) as precise as TBK-measured TBMM [TBMM = 1.29 + 0.00453 × TBK (mEq) + 1.46 (male) + 0.144 × weight (kg) - 0.0565 × age] (R2 = 0.930, P < 0.0001) or isotopic methods. BIS models were also developed for measuring leg and arm muscle mass. Conclusion: BIS provides an estimate of TBMM that correlates well with isotopic methods in approximating values obtained by MRI and can be used to estimate limb muscle mass.

AB - Background: Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive. Objective: We evaluated the use of multifrequency bioimpedance spectroscopy (BIS) measurements of intracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients. Design: TBMM was measured by MRI in 20 male and 18 female hemodialysis patients with a median (range) age of 54 y (33-73 y), weight of 78.9 kg (43.2-120 kg), and body mass index (BMI; in kg/m2) of 27.3 (19.4-46.6). We measured total body water (TBW) by using D2O dilution, extracellular volume (ECV) as bromide space, and ICV as TBW minus bromide space. Total body potassium (TBK) measured as 40K was used as an independent model of TBMM. BIS was used to measure whole-body TBW (ankle to wrist) and TBW in the arms and legs. BIS-estimated ICV was used to construct models to calculate limb muscle mass and TBMM. The latter was compared with models derived from isotopic methods. Results: BIS yielded a model for TBMM [TBMM = 9.52 + 0.331 × ICV + 2.77 (male) + 0.180 × weight (kg) - 0.133 × age] (R2 = 0.937, P < 0.0001) as precise as TBK-measured TBMM [TBMM = 1.29 + 0.00453 × TBK (mEq) + 1.46 (male) + 0.144 × weight (kg) - 0.0565 × age] (R2 = 0.930, P < 0.0001) or isotopic methods. BIS models were also developed for measuring leg and arm muscle mass. Conclusion: BIS provides an estimate of TBMM that correlates well with isotopic methods in approximating values obtained by MRI and can be used to estimate limb muscle mass.

KW - Bioimpedance spectroscopy

KW - Body cell mass

KW - Body composition

KW - Extracellular fluid

KW - Hemodialysis patients

KW - Nutrition

KW - Total body water

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