Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables

Richard Reiss, Jason Johnston, Kevin Tucker, John M. DeSesso, Carl L Keen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The current paper provides an analysis of the potential number of cancer cases that might be prevented if half the U.S. population increased its fruit and vegetable consumption by one serving each per day. This number is contrasted with an upper-bound estimate of concomitant cancer cases that might be theoretically attributed to the intake of pesticide residues arising from the same additional fruit and vegetable consumption. The cancer prevention estimates were derived using a published meta-analysis of nutritional epidemiology studies. The cancer risks were estimated using U.S. Environmental Protection Agency (EPA) methods, cancer potency estimates from rodent bioassays, and pesticide residue sampling data from the U.S. Department of Agriculture (USDA). The resulting estimates are that approximately 20,000 cancer cases per year could be prevented by increasing fruit and vegetable consumption, while up to 10 cancer cases per year could be caused by the added pesticide consumption. These estimates have significant uncertainties (e.g., potential residual confounding in the fruit and vegetable epidemiologic studies and reliance on rodent bioassays for cancer risk). However, the overwhelming difference between benefit and risk estimates provides confidence that consumers should not be concerned about cancer risks from consuming conventionally-grown fruits and vegetables.

Original languageEnglish (US)
Pages (from-to)4421-4427
Number of pages7
JournalFood and Chemical Toxicology
Volume50
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

vegetable consumption
Vegetables
fruit consumption
Fruits
Fruit
neoplasms
Pesticide Residues
Bioassay
Neoplasms
Epidemiology
pesticide residues
Environmental Protection Agency
Biological Assay
Pesticides
Rodentia
Agriculture
rodents
bioassays
vegetables
United States Department of Agriculture

Keywords

  • Cancer
  • Fruits
  • Pesticides
  • Vegetables

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables. / Reiss, Richard; Johnston, Jason; Tucker, Kevin; DeSesso, John M.; Keen, Carl L.

In: Food and Chemical Toxicology, Vol. 50, No. 12, 12.2012, p. 4421-4427.

Research output: Contribution to journalArticle

Reiss, Richard ; Johnston, Jason ; Tucker, Kevin ; DeSesso, John M. ; Keen, Carl L. / Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables. In: Food and Chemical Toxicology. 2012 ; Vol. 50, No. 12. pp. 4421-4427.
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