Estimation of acute fluid shifts using bioelectrical impedance analysis in horses

C. Langdon Fielding, K G Magdesian, Gary Carlson, Rebecca E. Ruby, Diane M. Rhodes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Multi-frequency bioelectrical impedance analysis (MF-BIA) has been used to evaluate extracellular fluid volume (ECFV), but not fluid fluxes associated with fluid or furosemide administration in horses. If able to detect acute changes in ECFV, MF-BIA would be useful in monitoring fluid therapy in horses. Hypothesis: The purpose of this study was to evaluate the ability of MF-BIA to detect acute fluid compartment changes in horses. We hypothesized that MF-BIA would detect clinically relevant (10-20%) changes in ECFV. Animals: Six healthy mares were used in the study. Methods: This is an original experimental study. Mares were studied in 3 experiments: (1) crystalloid expansion of normally hydrated subjects, (2) furosemide-induced dehydration followed by crystalloid administration, and (3) acute blood loss followed by readministration of lost blood. MF-BIA measurements were made before, during, and after each fluid shift and compared to known changes in volume calculated based on the intravenous fluids that were administered in addition to urinary fluid losses. Mean errors between MF-BIA estimated change and known volume change were compared using nonparametric analysis of variance. Estimated ECFV pre- and post-fluid administration similarly were compared. The level of statistical significance was set at P < .05. Results: Results of the study revealed a statistically significant change in ECFV and total body water during crystalloid expansion and dehydration. Statistically significant changes were not observed during blood loss and administration. Mean errors between MF-BIA results and measured net changes were small. Conclusions and Clinical Importance: MF-BIA represents a practical and accurate means of assessing acute fluid changes during dehydration and expansion of ECFV using isotonic crystalloids with potential clinical applications in equine critical care.

Original languageEnglish (US)
Pages (from-to)176-183
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume21
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Fluid Shifts
bioelectrical impedance
Electric Impedance
Horses
Extracellular Fluid
extracellular fluids
horses
Dehydration
furosemide
Furosemide
mares
blood
fluids
Body Water
Fluid Therapy
fluid therapy
Critical Care
Analysis of Variance
body water
analysis of variance

Keywords

  • Blood loss
  • Dehydration
  • Equine
  • Fluid balance
  • Hypovolemia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Estimation of acute fluid shifts using bioelectrical impedance analysis in horses. / Fielding, C. Langdon; Magdesian, K G; Carlson, Gary; Ruby, Rebecca E.; Rhodes, Diane M.

In: Journal of Veterinary Internal Medicine, Vol. 21, No. 1, 01.2007, p. 176-183.

Research output: Contribution to journalArticle

Fielding, C. Langdon ; Magdesian, K G ; Carlson, Gary ; Ruby, Rebecca E. ; Rhodes, Diane M. / Estimation of acute fluid shifts using bioelectrical impedance analysis in horses. In: Journal of Veterinary Internal Medicine. 2007 ; Vol. 21, No. 1. pp. 176-183.
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