Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone

K. F. McCarthy, S. Wientroub, M. Hale, A Hari Reddi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Implantation of demineralized diaphyseal bone matrix (DBM) into subcutaneous sites in allogeneic Long-Evans rats results in new endochondral bone formation accompanied by hematopoietic bone marrow differentiation in the newly formed ossicles. In the present study, we investigated the relationship between the time of appearance of hematopoietic stem cells (CFU-S) and those of certain postulated elements of the hematopoietic microenvironment, i.e., fibroblast colony-forming cells (CFC-F), colony-stimulating factors (CSF), and collagen types.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalExperimental Hematology
Volume12
Issue number2
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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