Establishment of a molecular genetic map of distal mouse chromosome 1: Further definition of a conserved linkage group syntenic with human chromosome 1q

Michael F Seldin, Herbert C. Morse, Renee C. LeBoeuf, Alfred D. Steinberg

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56 Scopus citations

Abstract

A linkage map of distal mouse chromosome 1 was constructed by restriction fragment length polymorphism analysis of DNAs from seven sets of recombinant inbred (RI) strains. The data obtained with seven probes on Southern hybridization combined with data from previous studies suggest the gene order Cfh, Pep-3/Ren-1,2, Ly-5, Lamb-2, At-3, Apoa-2/Ly-17, Spna-1. These results confirm and extend analyses of a large linkage group which includes genes present on a 20-30 cM span of mouse chromosome 1 and those localized to human chromosome 1q21-32. Moreover, the data indicate similar relative positions of human and mouse complement receptor-related genes REN, CD45, LAMB2, AT3, APOA2, and SPTA. These results suggest that mouse gene analyses may help in detailed mapping of human genes within such a syntenic group.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalGenomics
Volume2
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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