Essential tremor is not associated with cerebellar Purkinje cell loss

Claire Symanski, Holly A. Shill, Brittany Dugger, Joseph G. Hentz, Charles H. Adler, Sandra A. Jacobson, Erika Driver-Dunckley, Thomas G. Beach

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor (ET). The aim of this study was to examine whether ET is associated with Purkinje cell (PC) loss. Prospectively categorized ET and control subjects who were longitudinally examined in the Arizona Study for Aging and Neurodegenerative Disorders and came to autopsy between 1998 and 2013 underwent standardized neuropathological assessment of the brain. PC linear density of the cerebellar hemisphere was calculated in a blinded manner. There were 56 ET cases and 62 age-matched controls free of dementia and other neurodegenerative disorders included in the study. Mean PC linear density was 3.80±0.81 cells per mm for tremor cases and 3.82±0.91 cells per mm for controls (Δ 0.02; 95% confidence interval [CI]: -0.30-0.34). PC counts were not associated with tremor duration (r=0.06; 95% CI: -0.21-0.32). These data demonstrate that ET is not associated with cerebellar PC loss.

Original languageEnglish (US)
Pages (from-to)496-500
Number of pages5
JournalMovement Disorders
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Essential Tremor
Purkinje Cells
Cell Count
Tremor
Neurodegenerative Diseases
Confidence Intervals
Cerebellum
Dementia
Autopsy
Brain

Keywords

  • Aging
  • Brain bank
  • Cell loss
  • Tremor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Symanski, C., Shill, H. A., Dugger, B., Hentz, J. G., Adler, C. H., Jacobson, S. A., ... Beach, T. G. (2014). Essential tremor is not associated with cerebellar Purkinje cell loss. Movement Disorders, 29(4), 496-500. https://doi.org/10.1002/mds.25845

Essential tremor is not associated with cerebellar Purkinje cell loss. / Symanski, Claire; Shill, Holly A.; Dugger, Brittany; Hentz, Joseph G.; Adler, Charles H.; Jacobson, Sandra A.; Driver-Dunckley, Erika; Beach, Thomas G.

In: Movement Disorders, Vol. 29, No. 4, 01.01.2014, p. 496-500.

Research output: Contribution to journalArticle

Symanski, C, Shill, HA, Dugger, B, Hentz, JG, Adler, CH, Jacobson, SA, Driver-Dunckley, E & Beach, TG 2014, 'Essential tremor is not associated with cerebellar Purkinje cell loss', Movement Disorders, vol. 29, no. 4, pp. 496-500. https://doi.org/10.1002/mds.25845
Symanski C, Shill HA, Dugger B, Hentz JG, Adler CH, Jacobson SA et al. Essential tremor is not associated with cerebellar Purkinje cell loss. Movement Disorders. 2014 Jan 1;29(4):496-500. https://doi.org/10.1002/mds.25845
Symanski, Claire ; Shill, Holly A. ; Dugger, Brittany ; Hentz, Joseph G. ; Adler, Charles H. ; Jacobson, Sandra A. ; Driver-Dunckley, Erika ; Beach, Thomas G. / Essential tremor is not associated with cerebellar Purkinje cell loss. In: Movement Disorders. 2014 ; Vol. 29, No. 4. pp. 496-500.
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