Esophageal pathology in patients after treatment for head and neck cancer

D. Gregory Farwell, Catherine J. Rees, Debbie A. Mouadeb, Jacqueline Allen, Allen M. Chen, Danny J. Enepekides, Peter C. Belafsky

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: To determine the prevalence of esophageal pathology following treatment for primary head and neck cancer (HNCA). Study Design: Case series with planned data collection. Setting: Academic medical practice. Subjects and Methods: Subjects comprised HNCA survivors. Esophagoscopy was prospectively performed on 100 patients at least three months after treatment for HNCA. Patient demographics including cancer stage, cancer treatment, use of reflux medications, symptoms surveys, and esophageal findings were prospectively determined. Results: The mean age of the cohort was 64 (± 10) years; 75 percent were male. The mean time between the end of treatment and endoscopy was 40 (± 51) months. Eighty-one percent of HNCA was advanced stage (3 or 4). The distribution of site of the primary HNCA was as follows: oropharynx (38%), larynx (33%), oral cavity (17%), unknown primary (10%), hypopharynx (1%), and nasopharynx (1%). Treatment modalities included surgery alone (15%), surgery with radiation (34%), radiation alone (6%), chemoradiation alone (24%), and chemoradiation with surgery (20%). The findings on esophagoscopy included peptic esophagitis (63%), stricture (23%), candidiasis (9%), Barrett metaplasia (8%), gastritis (4%), and carcinoma (4%). Only 13 percent had a normal esophagoscopy. Conclusion: Esophageal pathology is extremely common in patients treated for HNCA. These findings support routine esophageal screening after HNCA treatment.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Issue number3
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)


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