Esophageal A-ring is associated with the severity of gastroesophageal reflux

Yuval Nachalon, Nogah Nativ-Zeltzer, Shumon I. Dhar, Omid B. Mehdizadeh, Antonio T. Cassady, Peter C Belafsky

Research output: Contribution to journalArticle

Abstract

Background: The esophageal A-ring (EAR) is an anatomic finding appreciated on videofluoroscopic esophagram (VFE) at the junction of the tubular esophagus and esophageal vestibule. EARs are appreciated on a small subset (5%) of VFEs. We hypothesize that EARs represent a compensatory mechanism to protect against gastroesophageal reflux (GER). Objective: To evaluate the association between EAR and GER. Study Design: Case control study. Methods: All persons having undergone ambulatory pH testing with an EAR identified on VFE between November 1, 2014 and June 30, 2014 were identified. All cases were matched to controls by age, gender, and the presence/absence of hiatal hernia. Subjective dysphagia severity was assessed with the EAT10 and the presence of erosive esophagitis and intestinal metaplasia on esophagoscopy was abstracted. Results: The mean (±SD) age of the entire cohort (N = 20) was 63 (±7.7) years. 60% was female. The mean composite DeMeester pH score for persons with and without an EAR was 48.9 (±39.6) and 15.4 (±12.3), respectively (P =.033). The mean total % time of pH < 4 for persons with and without an EAR was 26.4 (±21.9) and 7.7 (±6.8), respectively (P =.034). The prevalence of erosive esophagitis among persons with and without an EAR was 70% and 10%, respectively (P =.019). Conclusion: There is a significant association between the presence of esophageal A-rings on esophagography and the severity of acid reflux on endoscopy and ambulatory pH testing. The data suggest that the presence of an esophageal A-ring may be either a compensatory mechanism to protect against gastroesophageal reflux and/or an inflammatory consequence of peptic esophagitis. Level of Evidence: 3b Laryngoscope, 2019.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StatePublished - Jan 1 2019

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Gastroesophageal Reflux
Esophagitis
Esophagoscopy
Laryngoscopes
Peptic Esophagitis
Hiatal Hernia
Metaplasia
Deglutition Disorders
Esophagus
Endoscopy
Case-Control Studies
Acids

Keywords

  • A-ring
  • acid reflux
  • esophagus
  • GERD
  • stricture

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Esophageal A-ring is associated with the severity of gastroesophageal reflux. / Nachalon, Yuval; Nativ-Zeltzer, Nogah; Dhar, Shumon I.; Mehdizadeh, Omid B.; Cassady, Antonio T.; Belafsky, Peter C.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

Nachalon, Yuval ; Nativ-Zeltzer, Nogah ; Dhar, Shumon I. ; Mehdizadeh, Omid B. ; Cassady, Antonio T. ; Belafsky, Peter C. / Esophageal A-ring is associated with the severity of gastroesophageal reflux. In: Laryngoscope. 2019.
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abstract = "Background: The esophageal A-ring (EAR) is an anatomic finding appreciated on videofluoroscopic esophagram (VFE) at the junction of the tubular esophagus and esophageal vestibule. EARs are appreciated on a small subset (5{\%}) of VFEs. We hypothesize that EARs represent a compensatory mechanism to protect against gastroesophageal reflux (GER). Objective: To evaluate the association between EAR and GER. Study Design: Case control study. Methods: All persons having undergone ambulatory pH testing with an EAR identified on VFE between November 1, 2014 and June 30, 2014 were identified. All cases were matched to controls by age, gender, and the presence/absence of hiatal hernia. Subjective dysphagia severity was assessed with the EAT10 and the presence of erosive esophagitis and intestinal metaplasia on esophagoscopy was abstracted. Results: The mean (±SD) age of the entire cohort (N = 20) was 63 (±7.7) years. 60{\%} was female. The mean composite DeMeester pH score for persons with and without an EAR was 48.9 (±39.6) and 15.4 (±12.3), respectively (P =.033). The mean total {\%} time of pH < 4 for persons with and without an EAR was 26.4 (±21.9) and 7.7 (±6.8), respectively (P =.034). The prevalence of erosive esophagitis among persons with and without an EAR was 70{\%} and 10{\%}, respectively (P =.019). Conclusion: There is a significant association between the presence of esophageal A-rings on esophagography and the severity of acid reflux on endoscopy and ambulatory pH testing. The data suggest that the presence of an esophageal A-ring may be either a compensatory mechanism to protect against gastroesophageal reflux and/or an inflammatory consequence of peptic esophagitis. Level of Evidence: 3b Laryngoscope, 2019.",
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AU - Nativ-Zeltzer, Nogah

AU - Dhar, Shumon I.

AU - Mehdizadeh, Omid B.

AU - Cassady, Antonio T.

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AB - Background: The esophageal A-ring (EAR) is an anatomic finding appreciated on videofluoroscopic esophagram (VFE) at the junction of the tubular esophagus and esophageal vestibule. EARs are appreciated on a small subset (5%) of VFEs. We hypothesize that EARs represent a compensatory mechanism to protect against gastroesophageal reflux (GER). Objective: To evaluate the association between EAR and GER. Study Design: Case control study. Methods: All persons having undergone ambulatory pH testing with an EAR identified on VFE between November 1, 2014 and June 30, 2014 were identified. All cases were matched to controls by age, gender, and the presence/absence of hiatal hernia. Subjective dysphagia severity was assessed with the EAT10 and the presence of erosive esophagitis and intestinal metaplasia on esophagoscopy was abstracted. Results: The mean (±SD) age of the entire cohort (N = 20) was 63 (±7.7) years. 60% was female. The mean composite DeMeester pH score for persons with and without an EAR was 48.9 (±39.6) and 15.4 (±12.3), respectively (P =.033). The mean total % time of pH < 4 for persons with and without an EAR was 26.4 (±21.9) and 7.7 (±6.8), respectively (P =.034). The prevalence of erosive esophagitis among persons with and without an EAR was 70% and 10%, respectively (P =.019). Conclusion: There is a significant association between the presence of esophageal A-rings on esophagography and the severity of acid reflux on endoscopy and ambulatory pH testing. The data suggest that the presence of an esophageal A-ring may be either a compensatory mechanism to protect against gastroesophageal reflux and/or an inflammatory consequence of peptic esophagitis. Level of Evidence: 3b Laryngoscope, 2019.

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