Escape of mutant double-stranded DNA virus from innate immune control

Anthony R. French, Jeanette T. Pingel, Markus Wagner, Ivan Bubic, Liping Yang, Sung Jin Kim, Ulrich Koszinowski, Stipan Jonjic, Wayne M. Yokoyama

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA β-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity.

Original languageEnglish (US)
Pages (from-to)747-756
Number of pages10
JournalImmunity
Volume20
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    French, A. R., Pingel, J. T., Wagner, M., Bubic, I., Yang, L., Kim, S. J., Koszinowski, U., Jonjic, S., & Yokoyama, W. M. (2004). Escape of mutant double-stranded DNA virus from innate immune control. Immunity, 20(6), 747-756. https://doi.org/10.1016/j.immuni.2004.05.006