Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat

J. E. Carter, J. L. Tarigo, William Vernau, T. E. Cecere, R. L. Hovis, S. E. Suter

Research output: Contribution to journalArticle

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Abstract

A 13-year-old male castrated domestic shorthair cat was presented to the referring veterinarian with a 2-month history of weight loss and lethargy. Splenomegaly, hepatomegaly, nonregenerative anemia, neutropenia, and hyperbilirubinemia were noted. Results of testing for feline immunodeficiency virus, feline leukemia virus. Toxoplasma gondii, and Mycoplasma sp. were negative. On cytologic examination of aspirates from the enlarged spleen and liver, a population of erythrophagocytic round cells was observed. Splenectomy and a liver biopsy were done which revealed a population of CD3 + /CD79a- erythrophagocytic mononuclear round cells localized in the hepatic and splenic sinusoids. T-cell PARR (PCR for antigen receptor gene rearrangements) analysis of bone marrow and spleen demonstrated a single band indicative of a clonal proliferation of T cells. Based on the marked splenomegaly, sinusoidal infiltration, lack of lymph- adenopathy, and results of cytology, PARR, and immunophenotyping, a diagnosis of low-grade extranodal T-cell lymphoma was made. The cat was treated with chlorambucil and prednisolone; clinical and laboratory abnormalities resolved and the cat has remained clinically normal for 2.5 years. To our knowledge, this report documents the first case of an erythrophagocytic T-cell lymphoma in a cat. The clinicopathologic findings were suggestive of hepatosplenic T-cell lymphoma, a neoplasm described previously only in humans and dogs.

Original languageEnglish (US)
Pages (from-to)416-421
Number of pages6
JournalVeterinary Clinical Pathology
Volume37
Issue number4
DOIs
StatePublished - Dec 2008

Fingerprint

T-Cell Lymphoma
lymphoma
Splenomegaly
Cats
T-lymphocytes
cats
Hepatomegaly
splenomegaly
T-Lymphocyte Gene Rearrangement
liver
Feline Leukemia Virus
Feline Immunodeficiency Virus
Chlorambucil
spleen
Immunophenotyping
Polymerase Chain Reaction
Lethargy
Antigen Receptors
Hyperbilirubinemia
Veterinarians

Keywords

  • Cat
  • Erythrophagia
  • Hepatosplenic
  • Lymphoma
  • PARR

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Carter, J. E., Tarigo, J. L., Vernau, W., Cecere, T. E., Hovis, R. L., & Suter, S. E. (2008). Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat. Veterinary Clinical Pathology, 37(4), 416-421. https://doi.org/10.1111/j.1939-165X.2008.00073.x

Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat. / Carter, J. E.; Tarigo, J. L.; Vernau, William; Cecere, T. E.; Hovis, R. L.; Suter, S. E.

In: Veterinary Clinical Pathology, Vol. 37, No. 4, 12.2008, p. 416-421.

Research output: Contribution to journalArticle

Carter, J. E. ; Tarigo, J. L. ; Vernau, William ; Cecere, T. E. ; Hovis, R. L. ; Suter, S. E. / Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat. In: Veterinary Clinical Pathology. 2008 ; Vol. 37, No. 4. pp. 416-421.
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