Abstract
Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the compound was found to be totally ineffective in the treatment of experimentally induced systemic herpes simplex virus type 1 infections in Swiss mice. Data was obtained, however, which clearly indicated that the antiviral potency of 9-β-D-arabinofuranosyladenine in vivo could be enhanced by the co-administration of low, nontoxic doses of erythro-9-(2-hydroxy-3-nonyl)adenine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 598-603 |
| Number of pages | 6 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 18 |
| Issue number | 4 |
| State | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Erythro-9-(2-hydroxy-3-nonyl)adenine alone and in combination with 9-β-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice. / Shannon, W. M.; Arnett, G.; Schabel, F. M.; North, T. W.; Cohen, S. S.
In: Antimicrobial Agents and Chemotherapy, Vol. 18, No. 4, 1980, p. 598-603.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Erythro-9-(2-hydroxy-3-nonyl)adenine alone and in combination with 9-β-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice
AU - Shannon, W. M.
AU - Arnett, G.
AU - Schabel, F. M.
AU - North, T. W.
AU - Cohen, S. S.
PY - 1980
Y1 - 1980
N2 - Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the compound was found to be totally ineffective in the treatment of experimentally induced systemic herpes simplex virus type 1 infections in Swiss mice. Data was obtained, however, which clearly indicated that the antiviral potency of 9-β-D-arabinofuranosyladenine in vivo could be enhanced by the co-administration of low, nontoxic doses of erythro-9-(2-hydroxy-3-nonyl)adenine.
AB - Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the compound was found to be totally ineffective in the treatment of experimentally induced systemic herpes simplex virus type 1 infections in Swiss mice. Data was obtained, however, which clearly indicated that the antiviral potency of 9-β-D-arabinofuranosyladenine in vivo could be enhanced by the co-administration of low, nontoxic doses of erythro-9-(2-hydroxy-3-nonyl)adenine.
UR - http://www.scopus.com/inward/record.url?scp=0019163980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019163980&partnerID=8YFLogxK
M3 - Article
C2 - 6255863
AN - SCOPUS:0019163980
VL - 18
SP - 598
EP - 603
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
ER -