Errors associated with single-scan determinations of regional cerebral blood flow by xenon enhanced CT

W. F. Good, D. Gur, L. Shabason, S. K. Wolfson, H. Yonas, Richard E Latchaw, D. L. Herbert, W. H. Kennedy

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Possible errors in the determination of xenon concentrations in arterial blood, and uncertainties in CT tissue enhancements during inhalation of xenon-oxygen mixtures, are used to assess errors in the determination of regional cerebral blood flow by the in vivo autoradiographic (single-scan) technique. The results of this study indicate that errors associated with the determination of xenon concentrations in arterial blood decrease rapidly as the time of scanning after the initiation of xenon inhalation is increased. Analysis of errors caused by statistical uncertainties in image enhancement indicate that time of scanning is optimal between 1.5 and 2.5 min for determination of fast flow, while errors in single-flow determinations gradually decrease as the time of scanning increases.

Original languageEnglish (US)
Article number004
Pages (from-to)531-537
Number of pages7
JournalPhysics in Medicine and Biology
Volume27
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy (miscellaneous)
  • Biomedical Engineering

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